methyl (S)-3-(4-methoxyphenyl)-2-(4-nitrophenoxycarbonylamino)propionate

Base Information

• Chemical Name: methyl (S)-3-(4-methoxyphenyl)-2-(4-nitrophenoxycarbonylamino)propionate
• CAS No.: 1225591-94-5
• Molecular Formula: C₁₈H₁₈N₂O₇
• Molecular Weight: 374.35

Synonyms:methyl (S)-3-(4-methoxyphenyl)-2-(4-nitrophenoxycarbonylamino)propionate

Chemical Property of methyl (S)-3-(4-methoxyphenyl)-2-(4-nitrophenoxycarbonylamino)propionate

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Technology Process of methyl (S)-3-(4-methoxyphenyl)-2-(4-nitrophenoxycarbonylamino)propionate

There total 1 articles about methyl (S)-3-(4-methoxyphenyl)-2-(4-nitrophenoxycarbonylamino)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (S)-2-amino-3-(4-methoxyphenyl)propionate (17355-19-0) + 4-Nitrophenyl chloroformate (7693-46-1) → methyl (S)-3-(4-methoxyphenyl)-2-(4-nitrophenoxycarbonylamino)propionate (1225591-94-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Cooling with bath of cold water;

Reference yield: 100.0%

methyl (S)-3-(4-methoxyphenyl)-2-(4-nitrophenoxycarbonylamino)propionate (1225591-94-5) + ethyl[2-(1H-imidazol-4-yl)ethyl]amine hydrochloride → methyl (S)-2-{3-ethyl-3-[2-(1H-imidazol-4-yl)ethyl]ureido}-3-(4-methoxyphenyl)-propionate (1225652-58-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 - 80 ℃;

Reference yield: 63.0%

methyl (S)-3-(4-methoxyphenyl)-2-(4-nitrophenoxycarbonylamino)propionate (1225591-94-5) + imidazole-4-methanamine dihydrochloride (66247-84-5,72631-80-2) → methyl (S)-2-[3-(1H-imidazol-4-yl-methyl)ureido]-3-(4-methoxyphenyl)-propanoate (1225653-10-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

upstream raw materials:

methyl (S)-2-amino-3-(4-methoxyphenyl)propionate

4-Nitrophenyl chloroformate

Downstream raw materials:

methyl (S)-2-{3-[2-(1H-imidazol-4-yl)ethyl]ureido}-3-(4-methoxyphenyl)-propanoate

methyl (S)-2-[3-(1H-imidazol-4-yl-methyl)ureido]-3-(4-methoxyphenyl)-propanoate

methyl (S)-2-{3-ethyl-3-[2-(1H-imidazol-4-yl)ethyl]ureido}-3-(4-methoxyphenyl)-propionate

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