4-(3-(cyclopropylmethyl)ureido)-N-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)pyrrolidin-3-yl)-N-methylbenzamide

Base Information

Chemical Name:4-(3-(cyclopropylmethyl)ureido)-N-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)pyrrolidin-3-yl)-N-methylbenzamide
CAS No.:1299488-54-2
Molecular Formula:C₂₇H₃₀F₆N₄O₃
Molecular Weight:572.551
Hs Code.:

Synonyms:4-(3-(cyclopropylmethyl)ureido)-N-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)pyrrolidin-3-yl)-N-methylbenzamide

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Chemical Property of 4-(3-(cyclopropylmethyl)ureido)-N-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)pyrrolidin-3-yl)-N-methylbenzamide

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Technology Process of 4-(3-(cyclopropylmethyl)ureido)-N-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)pyrrolidin-3-yl)-N-methylbenzamide

There total 5 articles about 4-(3-(cyclopropylmethyl)ureido)-N-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)pyrrolidin-3-yl)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 202134-57-4
2-(4-(bromomethyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

: 1299488-55-3
4-(3-(cyclopropylmethyl)ureido)-N-methyl-N-(pyrrolidin-3-yl)benzamide

: 1299488-54-2
4-(3-(cyclopropylmethyl)ureido)-N-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)pyrrolidin-3-yl)-N-methylbenzamide

Guidance literature:: With potassium carbonate; In acetonitrile; for 5h; Reflux;

Reference yield:

: 1022822-12-3
ethyl 4-(3-(cyclopropylmethyl)ureido)benzoate

: 1299488-54-2
4-(3-(cyclopropylmethyl)ureido)-N-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)pyrrolidin-3-yl)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / ethanol / Reflux

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 h

3: trifluoroacetic acid / dichloromethane / 20 h

4: potassium carbonate / acetonitrile / 5 h / Reflux

With potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; acetonitrile;

Reference yield:

: 1196691-39-0
4-(3-(cyclopropylmethyl)ureido)benzoic acid

: 1299488-54-2
4-(3-(cyclopropylmethyl)ureido)-N-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)pyrrolidin-3-yl)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 h

2: trifluoroacetic acid / dichloromethane / 20 h

3: potassium carbonate / acetonitrile / 5 h / Reflux

With potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;