100923-73-7

Upstream product

• 108-69-0 3,5-dimethylaminoaniline 

Downstream Products

• 60999-76-0 1-(4-methoxy-2,6-dimethylphenyl)ethanone 
• 1216222-72-8 1-(4-ethoxy-2,6-dimethylphenyl)ethanone 
• 91060-92-3 1-(4-hydroxy-2,6-dimethylphenyl)ethanone 
• 1310320-06-9 2-bromo-1-(4-methoxy-2,6-dimethylphenyl)ethanone 
• 1334921-86-6 2-bromo-1-(4-ethoxy-2,6-dimethylphenyl)ethanone 
• 1216250-42-8 4-(4-methoxy-2,6-dimethylphenyl)thiazol-2-amine 
• 1334921-87-7 4-(4-ethoxy-2,6-dimethylphenyl)thiazol-2-amine 
• 118738-91-3 1-(4-iodo-2,6-dimethylphenyl)ethanone 
• 1334921-90-2 4-acetyl-3,5-dimethylphenyl trifluoromethanesulfonate 
• 1439935-79-1 1-(4-amino-2,6-dimethylphenyl)-2-bromoethanone 
• 779293-65-1 N-(4-(2-aminothiazol-4-yl)-3,5-dimethylphenyl)acetamide 
• 136382-02-0 N-(4-(2-bromoacetyl)-3,5-dimethylphenyl)acetamide 

Relevant academic research and scientific papers

Aerobic intramolecular carbon-hydrogen bond oxidation promoted by Cu(i) complexes

The oxidation of C-H bonds by copper centres in enzymes with molecular oxygen takes place in nature under ambient conditions. Herein we report a similar transformation in which under ambient pressure and temperature (1 atm, 25 °C) the complex TpMsCu(THF)

4 - (4 - ((9H - purine - 6 - yl) thio) phenyl) thiazolyl - 2 - amine derivative and its preparation and use

The invention belongs to the field of chemical medicine and particularly relates to a 4-(4-((9H-purine-6-base)sulphur)phenyl)thiazolyl-2-amine derivative and a preparation method and application thereof. The structure of the 4-(4-((9H-purine-6-base)sulphur)phenyl)thiazolyl-2-amine derivative is shown in the formula I. The preparation method of the 4-(4-((9H-purine-6-base)sulphur)phenyl)thiazolyl-2-amine derivative and the application of the 4-(4-((9H-purine-6-base)sulphur)phenyl)thiazolyl-2-amine derivative in preparation of medicine for treating tumors are further provided. The synthetic route is short, reaction conditions are simple, the yield is high, and derivatization is easy. A series of compounds have good anti-tumor activity and low toxicity. A new choice is provided for preparation of the anti-tumor medicine. See the formula in the specification.

Synthesis and biological evaluation of N-(4-phenylthiazol-2-yl)cinnamamide derivatives as novel potential anti-tumor agents

In this study, a series of novel N-(4-phenylthiazol-2-yl)cinnamamide derivatives (7a-8n) were synthesized and evaluated for their anti-proliferative activities in vitro by MTT assay and a possible antitumor mechanism was also explored. SAR analysis showed that steric effects played an important role on the anti-tumor activity. The most potent analogue 8f showed excellent inhibitions on the K562, Bel7402, A549 and Jurkat cells ranging from sub-micromolar to nanomolar concentration. Compound 8f inhibited Jurkat cells with an IC50 value of 0.035 μM with no apparent toxicity in different non-cancerous cells. Furthermore, it was suggested that the possible mechanism of 8f might be associated with inducing cancer cell apoptosis following flow cytometer analysis and Hoechst 33358 staining assays.