(S)-2-((S)-2-Hydroxy-2-phenyl-ethylsulfanyl)-1-phenyl-ethanol

Base Information

• Chemical Name: (S)-2-((S)-2-Hydroxy-2-phenyl-ethylsulfanyl)-1-phenyl-ethanol
• CAS No.: 212965-33-8
• Molecular Formula: C₁₆H₁₈O₂S
• Molecular Weight: 274.384
• Mol file: 212965-33-8.mol

Synonyms:(S)-2-((S)-2-Hydroxy-2-phenyl-ethylsulfanyl)-1-phenyl-ethanol

Chemical Property of (S)-2-((S)-2-Hydroxy-2-phenyl-ethylsulfanyl)-1-phenyl-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((S)-2-Hydroxy-2-phenyl-ethylsulfanyl)-1-phenyl-ethanol

There total 5 articles about (S)-2-((S)-2-Hydroxy-2-phenyl-ethylsulfanyl)-1-phenyl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(S)-1-phenyl-2-(tosyloxy)ethanol (40435-14-1) → (S)-2-((S)-2-Hydroxy-2-phenyl-ethylsulfanyl)-1-phenyl-ethanol (212965-33-8)

Guidance literature:

With sodium sulfide; In acetone; at 70 ℃;

DOI:10.1016/S0957-4166(98)00224-9

Reference yield:

(S)-(-)-ethyl mandelate (13704-09-1) → (S)-2-((S)-2-Hydroxy-2-phenyl-ethylsulfanyl)-1-phenyl-ethanol (212965-33-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / TosOH*H₂O / 1 h / 0 °C

2: 98 percent / LiAlH₄ / diethyl ether / -20 °C

3: pyridine / Ambient temperature

4: 18percent aq. HCl / CH₂Cl₂

5: 82 percent / Na₂S*H₂O / acetone / 70 °C

With pyridine; hydrogenchloride; sodium sulfide; lithium aluminium tetrahydride; toluene-4-sulfonic acid; In diethyl ether; dichloromethane; acetone;

DOI:10.1016/S0957-4166(98)00224-9

Reference yield:

(2S,4RS)-2-Phenyl-4-methyl-3,5-dioxaheptan-1-ol (208458-94-0) → (S)-2-((S)-2-Hydroxy-2-phenyl-ethylsulfanyl)-1-phenyl-ethanol (212965-33-8)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / Ambient temperature

2: 18percent aq. HCl / CH₂Cl₂

3: 82 percent / Na₂S*H₂O / acetone / 70 °C

With pyridine; hydrogenchloride; sodium sulfide; In dichloromethane; acetone;

DOI:10.1016/S0957-4166(98)00224-9

upstream raw materials:

(S)-1-phenyl-2-(tosyloxy)ethanol

(S)-(-)-ethyl mandelate

(2S,4RS)-2-Phenyl-4-methyl-3,5-dioxaheptan-1-ol

(S)-(1-Ethoxy-ethoxy)-phenyl-acetic acid ethyl ester

Downstream raw materials:

(S,S)-(+)-bis(2-phenyl-2-chloroethyl)sulfide

rac-bis-1,2-(ethylsulfanyl)-1-phenylethane