208458-94-0

Upstream product

• 17199-29-0 (S)-Mandelic acid 
• 109-92-2 ethyl vinyl ether 
• 13704-09-1 (S)-(-)-ethyl mandelate 
• 212965-31-6 (S)-(1-Ethoxy-ethoxy)-phenyl-acetic acid ethyl ester 

Downstream Products

• 208458-95-1 (4S,6RS)-4-Phenyl-6-methyl-2,5,7-trioxanonan 
• 212965-35-0 Toluene-4-sulfonic acid (S)-2-(1-ethoxy-ethoxy)-2-phenyl-ethyl ester 
• 65487-97-0 (S)-(+)-2-methoxy-1-phenylethanol 
• 212965-33-8 (S)-2-((S)-2-Hydroxy-2-phenyl-ethylsulfanyl)-1-phenyl-ethanol 
• 40435-14-1 (S)-1-phenyl-2-(tosyloxy)ethanol 

Relevant academic research and scientific papers

Novel synthesis of chiral, enantiomerically pure thiodiglycols and diglycols

Natural α-hydroxy acids have been converted in a sequence of O- protection, reduction, O-activation, thioether and ether formation and deprotection to chiral, non-racemic β,β'-dihydroxy thioethers 1a, 1b and ether 1c. Overall yields are excellent (75%). In an attempt to synthesize the respective dihydroxy ether 1d derived from mandelic acid 1,3-dioxolane derivatives 7 were obtained.

Enantioselective catalysis CXXI [1]: Chiral phosphane ligands with additional oxygen functionalities

New optically active phosphane ligands with additional ether and hydroxy functionalities were synthesied and used as sources of enantio-selectivity in the Ni-catalyzed cross coupling reaction of 1-phenylethyl Grignard and vinylbromide and in the Pd-catalyzed allylation of 1,5-dimethylbarbituric acid with allyl acetate.