tert-butyl4-(4-(3-(2-chloro-6-fluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl4-(4-(3-(2-chloro-6-fluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
CAS No.:1402558-60-4
Molecular Formula:C₃₀H₃₄ClFN₆O₅S
Molecular Weight:645.155
Hs Code.:

Synonyms:tert-butyl4-(4-(3-(2-chloro-6-fluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

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Chemical Property of tert-butyl4-(4-(3-(2-chloro-6-fluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

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Technology Process of tert-butyl4-(4-(3-(2-chloro-6-fluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

There total 6 articles about tert-butyl4-(4-(3-(2-chloro-6-fluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl 4-(4,5-dihydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl)piperidine-1-carboxylate

: 1254566-97-6
N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-chloro-4-fluorophenyl)propane-1-sulfonamide

: 1402558-60-4
tert-butyl4-(4-(3-(2-chloro-6-fluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; dimethyl sulfoxide; at 100 ℃; for 0.0333333h; Inert atmosphere;

Reference yield:

: 434-75-3
2-chloro-6-fluorobenzoic acid

: 1402558-60-4
tert-butyl4-(4-(3-(2-chloro-6-fluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 1 h / 0 °C / Inert atmosphere

2.1: thionyl chloride / 2 h / Reflux

3.1: aluminum (III) chloride / dichloromethane / 1 h / 5 °C / Inert atmosphere

3.2: 6 h / 20 °C

4.1: acetic acid / iron / ethanol; water / 2 h / Reflux

5.1: dmap / dichloromethane; tetrahydrofuran / 20 °C

6.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; dimethyl sulfoxide / 0.03 h / 100 °C / Inert atmosphere

With aluminum (III) chloride; thionyl chloride; potassium carbonate; acetic acid; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; iron; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; 6.1: Suzuki Coupling;

Reference yield:

: 1402558-52-4
2-chloro-6-fluoro-3-nitrobenzoyl chloride

: 1402558-60-4
tert-butyl4-(4-(3-(2-chloro-6-fluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: aluminum (III) chloride / dichloromethane / 1 h / 5 °C / Inert atmosphere

1.2: 6 h / 20 °C

2.1: acetic acid / iron / ethanol; water / 2 h / Reflux

3.1: dmap / dichloromethane; tetrahydrofuran / 20 °C

4.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; dimethyl sulfoxide / 0.03 h / 100 °C / Inert atmosphere

With aluminum (III) chloride; potassium carbonate; acetic acid; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; iron; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; 4.1: Suzuki Coupling;