434-75-3

Basic information

• Product Name: 2-Chloro-6-fluorobenzoic acid
• Synonyms: LABOTEST-BB LT00454355;2-CHLORO-6-FLUOROBENZOIC ACID;RARECHEM AL BO 0022;Benzoic acid, 2-chloro-6-fluoro-;2-Chloro-6-fluorobenzoic acid, 98+%;2-Chloro-6-fluorobenzoic acid 97%;2-Chloro-6-fluorobenzoicacid97%;2-CHLORO-6-FLUROBENZOIC ACID pure
• CAS NO: 434-75-3
• Molecular Formula: C₇H₄ClFO₂
• Molecular Weight: 174.56
• EINECS: 207-105-2
• Product Categories: FINE Chemical & INTERMEDIATES;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Fluorobenzene;C7;Carbonyl Compounds;Carboxylic Acids;Aryl Fluorinated Building Blocks;Building Blocks;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Fluorine series
• Mol File: 434-75-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 155-157 °C(lit.)
• Boiling Point: 263.7 °C at 760 mmHg
• Flash Point: 113.3 °C
• Appearance: White to light yellow crystal powder
• Density: 1.4016 (estimate)
• Vapor Pressure: 0.00511mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.04±0.10(Predicted)
• BRN: 973857
• CAS DataBase Reference: 2-Chloro-6-fluorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-fluorobenzoic acid(434-75-3)
• EPA Substance Registry System: 2-Chloro-6-fluorobenzoic acid(434-75-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-37/38-36-20/21/22
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 434-75-3(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow crystal powder

Uses

2-Chloro-6-fluorobenzoic Acid is a versatile reactant used in the synthesis of biaryls via decarboxylative Pd-catalyzed cross-coupling with aryl iodides. Also used in the preparation of fluorinated biaryls and heterobiaryls using copper catalyzed decarboxylative cross-coupling of aryl and heteroalyl iodides or bromides with potassium polyfluorobenzoates.

General Description

2-Chloro-6-fluorobenzoic acid is a two-fold halogenated derivative of benzoic acid.

InChI:InChI=1/C7H4ClFO2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,(H,10,11)

Upstream product

• 387-45-1 2-chloro-6-fluorobenzaldehyde 
• 124-38-9 carbon dioxide 
• 625-98-9 3-chlorofluorobenzene 
• 95-52-3 2-Fluorotoluene 
• 668-45-1 2-chloro-6-fluorobenzonitrile 
• 443-33-4 N-[(2-chloro-6-fluorophenyl)methylidene]hydroxylamine 
• 443-83-4 2-chloro-6-fluorotoluene 

Downstream Products

• 363-51-9 2-chloro-6-fluoroaniline 
• 1206164-19-3 potassium 2-fluoro-6-chlorobenzoate 
• 1094457-24-5 (2-chloro-6-fluorophenyl)(4-methoxyphenyl)methanone 
• 2436-96-6 1-nitro-2-(2-nitrophenyl)benzene 
• 1352638-60-8 2-chloro-6-fluoro-2'-nitro-1,1'-biphenyl 
• 1352638-63-1 C₁₂H₆Cl₂F₂ 
• 1363397-35-6 tert-butyl 4-((2-chloro-6-fluorobenzoyloxy)methyl)thiazol-2-ylcarbamate 
• 1254566-97-6 N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-chloro-4-fluorophenyl)propane-1-sulfonamide 
• 1402558-52-4 2-chloro-6-fluoro-3-nitrobenzoyl chloride 
• 1402558-62-6 N-(2-chloro-4-fluoro-3-(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)propane-1-sulfonamide 
• 1402558-60-4 tert-butyl4-(4-(3-(2-chloro-6-fluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate 
• 1016522-68-1 N-(4-aminophenyl)-2-chloro-6-fluorobenzamide 
• 895700-93-3 2-chloro-6-fluoro-N-(4-(trifluoromethyl)phenyl)benzamide 
• 1572516-34-7 6-chloro-2-fluoro-3-[(3-methyloxetan-3-yl)sulfamoyl]benzoic acid 

Relevant articles and documents

RORγ MODULATORS

The invention provides an RORγ receptor agonist comprising a compound of formula (I), wherein the variables are as defined herein. These compounds are analogous to known RORγ receptor antagonists. The invention further provides a method of activating -the nuclear receptor RORγ, comprising -contacting the RORγ with an effective amount or concentration of a compound of the invention; and a method of treating cancer in a patient, comprising administering to the patient an effective dose of a compound of the invention.

An efficient one pot method for synthesis of carboxylic acids from nitriles using recyclable ionic liquid [bmim]HSO4 Dedicated to my mentor Professor (Mrs.) Krishna Misra on her 76th birthday

Environmentally benign ionic liquid [bmim]HSO4 was found suitable for conversion of nitriles into carboxylic acids under mild conditions with excellent purity.

Regioselective ortho-lithiation of chloro and bromo substituted fluoroarenes

Deprotonation of fluoroarenes carrying chlorine or bromine as additional substituents occurs always at a fluorine adjacent position if accomplished with potassium tert-butoxide activated butyllithium or lithium 2,2,6,6-tetramethylpiperidide.