3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-oxouridine

Base Information

Chemical Name:3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-oxouridine
CAS No.:1372710-50-3
Molecular Formula:C₂₆H₃₀N₂O₆Si
Molecular Weight:494.62
Hs Code.:

Synonyms:3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-oxouridine

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Chemical Property of 3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-oxouridine

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Technology Process of 3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-oxouridine

There total 4 articles about 3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-oxouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1372710-50-3
3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-oxouridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; tert-butyldimethylsilyl chloride / 12 h / 20 °C

1.2: 12 h / 20 °C

1.3: 3 h / 20 °C

2.1: dichloro-acetic acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide / 16 h / 20 °C

With pyridine; dichloro-acetic acid; tert-butyldimethylsilyl chloride; dimethyl sulfoxide; dicyclohexyl-carbodiimide; 2.1: Pfitzner-Moffatt oxidation;
DOI:10.1002/ejoc.201101353

Reference yield:

: C₄₇H₅₀N₂O₈Si

: 1372710-50-3
3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-oxouridine

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid; methanol / dichloromethane / 0.17 h / 4 °C

2: dicyclohexyl-carbodiimide; trifluoroacetic acid; dimethyl sulfoxide; pyridine / 20 h / 20 °C

With pyridine; methanol; toluene-4-sulfonic acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 2'-OMe-U

: 1372710-50-3
3'-O-(tert-butyldiphenylsilyl)-2'-O-methyl-5'-oxouridine

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 20 °C

2: toluene-4-sulfonic acid; methanol / dichloromethane / 0.17 h / 4 °C

3: dicyclohexyl-carbodiimide; trifluoroacetic acid; dimethyl sulfoxide; pyridine / 20 h / 20 °C

With pyridine; 1H-imidazole; methanol; toluene-4-sulfonic acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;