methyl 2,6-dimethoxy-1-(3'-trimethylsilyloxybutyl)-2,5-cyclohexadiene-1-carboxylate

Base Information

Chemical Name:methyl 2,6-dimethoxy-1-(3'-trimethylsilyloxybutyl)-2,5-cyclohexadiene-1-carboxylate
CAS No.:80900-45-4
Molecular Formula:C₁₇H₃₀O₅Si
Molecular Weight:342.508
Hs Code.:

Synonyms:methyl 2,6-dimethoxy-1-(3'-trimethylsilyloxybutyl)-2,5-cyclohexadiene-1-carboxylate

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Chemical Property of methyl 2,6-dimethoxy-1-(3'-trimethylsilyloxybutyl)-2,5-cyclohexadiene-1-carboxylate

Chemical Property:

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Technology Process of methyl 2,6-dimethoxy-1-(3'-trimethylsilyloxybutyl)-2,5-cyclohexadiene-1-carboxylate

There total 1 articles about methyl 2,6-dimethoxy-1-(3'-trimethylsilyloxybutyl)-2,5-cyclohexadiene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2065-27-2
methyl 2,6-dimethoxybenzoate

: 80900-43-2
(3-Iodo-1-methylpropoxy)trimethylsilane

: 80900-45-4
methyl 2,6-dimethoxy-1-(3'-trimethylsilyloxybutyl)-2,5-cyclohexadiene-1-carboxylate

Guidance literature:: With potassium; lithium bromide; Yield given. Multistep reaction; 1.) potassium in liquid ammonia, -78 grad C, (THF, t-BuOH, N₂ atm., 15 min.); 2.) LiBr; 3.) compound 8 (R₁=H);
DOI:10.1016/S0040-4039(01)82080-3

Reference yield: 97.0%

: 80900-45-4
methyl 2,6-dimethoxy-1-(3'-trimethylsilyloxybutyl)-2,5-cyclohexadiene-1-carboxylate

: 108161-74-6
1-hydroxymethyl-2,6-dimethoxy-1-(3'-trimethylsiloxybutyl)-2,5-cyclohexadiene

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 0.25h; Ambient temperature;
DOI:10.1016/S0040-4020(01)90577-0

Reference yield:

: 80900-45-4
methyl 2,6-dimethoxy-1-(3'-trimethylsilyloxybutyl)-2,5-cyclohexadiene-1-carboxylate

: 80900-53-4
2,6-dimethoxy-1-(methoxymethyloxymethyl)-1-(3'-oxobutyl)-2,5-cyclohexadiene

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / LiAlH₄ / diethyl ether / 0.25 h / Ambient temperature

2: 96 percent / ethyldiisopropylamine / CH₂Cl₂ / 24 h / Ambient temperature

3: 98 percent / KF, pH 6.8 buffer / methanol / 17 h / Ambient temperature

4: 59 percent / trifluoroacetic acid, pyridine, dicyclohexylcarboximide (DCC) / dimethylsulfoxide; benzene / 24 h / Ambient temperature

With pyridine; potassium fluoride; lithium aluminium tetrahydride; pH 6.8 buffer; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; benzene;
DOI:10.1016/S0040-4020(01)90577-0