1,4-bis((2-hydroxyethyl 4-O-tert-butyldimethylsilyl-2,3,6-trideoxy-3-N-p-nitrobenzenesulfonylamino-α-D-arabino-hexopyranosid-3-yl)methyl)benzene

Base Information

Chemical Name:1,4-bis((2-hydroxyethyl 4-O-tert-butyldimethylsilyl-2,3,6-trideoxy-3-N-p-nitrobenzenesulfonylamino-α-D-arabino-hexopyranosid-3-yl)methyl)benzene
CAS No.:611210-61-8
Molecular Formula:C₄₈H₇₄N₄O₁₆S₂Si₂
Molecular Weight:1083.44
Hs Code.:

1,4-bis((2-hydroxyethyl 4-O-tert-butyldimethylsilyl-2,3,6-trideoxy-3-N-p-nitrobenzenesulfonylamino-α-D-arabino-hexopyranosid-3-yl)methyl)benzene

Synonyms:1,4-bis((2-hydroxyethyl 4-O-tert-butyldimethylsilyl-2,3,6-trideoxy-3-N-p-nitrobenzenesulfonylamino-α-D-arabino-hexopyranosid-3-yl)methyl)benzene

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Chemical Property of 1,4-bis((2-hydroxyethyl 4-O-tert-butyldimethylsilyl-2,3,6-trideoxy-3-N-p-nitrobenzenesulfonylamino-α-D-arabino-hexopyranosid-3-yl)methyl)benzene

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Technology Process of 1,4-bis((2-hydroxyethyl 4-O-tert-butyldimethylsilyl-2,3,6-trideoxy-3-N-p-nitrobenzenesulfonylamino-α-D-arabino-hexopyranosid-3-yl)methyl)benzene

There total 8 articles about 1,4-bis((2-hydroxyethyl 4-O-tert-butyldimethylsilyl-2,3,6-trideoxy-3-N-p-nitrobenzenesulfonylamino-α-D-arabino-hexopyranosid-3-yl)methyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 611210-60-7
1,4-bis((2-tert-butyldimethylsilyloxyethyl 4-O-tert-butyldimethylsilyl-2,3,6-trideoxy-3-N-p-nitrobenzenesulfonylamino-α-D-arabino-hexopyranosid-3-yl)methyl)benzene

: 611210-61-8
1,4-bis((2-hydroxyethyl 4-O-tert-butyldimethylsilyl-2,3,6-trideoxy-3-N-p-nitrobenzenesulfonylamino-α-D-arabino-hexopyranosid-3-yl)methyl)benzene

Guidance literature:: With pyridine hydrogenfluoride; In pyridine; at 25 ℃; for 2h;
DOI:10.1016/S0040-4020(03)00820-2

Reference yield:

: 72075-74-2,72002-52-9
methyl 3-azido-2,3,6-trideoxy-α-D-arabino-hexopyranoside

: 611210-61-8
1,4-bis((2-hydroxyethyl 4-O-tert-butyldimethylsilyl-2,3,6-trideoxy-3-N-p-nitrobenzenesulfonylamino-α-D-arabino-hexopyranosid-3-yl)methyl)benzene

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / BF₃*OEt₂ / 0.83 h / 0 °C

2: 80 percent / molecular sieves 4 Angstroem; NBS / acetonitrile / 0.25 h / 0 °C

3: 40 percent / imidazole / CH₂Cl₂ / 0.17 h / 0 °C

4: 99 percent / H₂ / Pd/CaCO₃ / ethanol / 16 h / 25 °C

5: 72 percent / K₂CO₃ / CH₂Cl₂ / 2 h / 25 °C

6: 100 percent / 2,6-lutidine / CH₂Cl₂ / 16 h / 40 °C

7: 41 percent / K₂CO₃ / dimethylformamide / 3 h / 25 °C

8: 95 percent / HF*py / pyridine / 2 h / 25 °C

With 1H-imidazole; 2,6-dimethylpyridine; N-Bromosuccinimide; 4 A molecular sieve; boron trifluoride diethyl etherate; hydrogen; potassium carbonate; pyridine hydrogenfluoride; Lindlar's catalyst; In pyridine; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4020(03)00820-2

Reference yield:

: 611210-55-0
(2R,3S,4R)-4-Azido-6-(2-hydroxy-ethoxy)-2-methyl-tetrahydro-pyran-3-ol

: 611210-61-8
1,4-bis((2-hydroxyethyl 4-O-tert-butyldimethylsilyl-2,3,6-trideoxy-3-N-p-nitrobenzenesulfonylamino-α-D-arabino-hexopyranosid-3-yl)methyl)benzene

Guidance literature:: Multi-step reaction with 6 steps

1: 40 percent / imidazole / CH₂Cl₂ / 0.17 h / 0 °C

2: 99 percent / H₂ / Pd/CaCO₃ / ethanol / 16 h / 25 °C

3: 72 percent / K₂CO₃ / CH₂Cl₂ / 2 h / 25 °C

4: 100 percent / 2,6-lutidine / CH₂Cl₂ / 16 h / 40 °C

5: 41 percent / K₂CO₃ / dimethylformamide / 3 h / 25 °C

6: 95 percent / HF*py / pyridine / 2 h / 25 °C

With 1H-imidazole; 2,6-dimethylpyridine; hydrogen; potassium carbonate; pyridine hydrogenfluoride; Lindlar's catalyst; In pyridine; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(03)00820-2