N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-methylpropanamide

Base Information

Chemical Name:N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-methylpropanamide
CAS No.:916052-87-4
Molecular Formula:C₂₂H₁₈ClN₅O₂S
Molecular Weight:451.936
Hs Code.:

Synonyms:N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-methylpropanamide

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Chemical Property of N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-methylpropanamide

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Technology Process of N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-methylpropanamide

There total 7 articles about N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: N-(3-amino-2-chlorophenyl)-2-methylpropanamide

: 916052-15-8
(5Z)-2-(methylthio)-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one

: 916052-87-4
N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-methylpropanamide

Guidance literature:: In valeric acid; at 140 ℃; for 1h;

Reference yield:

: 6344-72-5
6-methylquinoxaline

: 916052-87-4
N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-methylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: selenium(IV) oxide / 1,4-dioxane / 3 h / 220 °C / Microwave heating

2: sodium acetate / acetic acid / 18 h / Heating / reflux

3: triethylamine / ethanol / 4 h / 20 °C

4: valeric acid / 1 h / 140 °C

With selenium(IV) oxide; sodium acetate; triethylamine; In 1,4-dioxane; ethanol; acetic acid; valeric acid;

Reference yield:

: (5Z)-5-(6-quinoxalinylmethylidene)-2-thioxo-1,3-thiazolidin-4-one

: 916052-87-4
N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-methylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / 4 h / 20 °C

2: valeric acid / 1 h / 140 °C

With triethylamine; In ethanol; valeric acid;