5-chloro-3-[1-{5-[3-(4-methyl-[1,4]diazepane-1-carbonyl)phenyl]furan-2-yl}propylidene]-1,3-dihydroindol-2-one

Base Information

Chemical Name:5-chloro-3-[1-{5-[3-(4-methyl-[1,4]diazepane-1-carbonyl)phenyl]furan-2-yl}propylidene]-1,3-dihydroindol-2-one
CAS No.:1353859-03-6
Molecular Formula:C₂₈H₂₈ClN₃O₃
Molecular Weight:490.002
Hs Code.:

Synonyms:5-chloro-3-[1-{5-[3-(4-methyl-[1,4]diazepane-1-carbonyl)phenyl]furan-2-yl}propylidene]-1,3-dihydroindol-2-one

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Chemical Property of 5-chloro-3-[1-{5-[3-(4-methyl-[1,4]diazepane-1-carbonyl)phenyl]furan-2-yl}propylidene]-1,3-dihydroindol-2-one

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Technology Process of 5-chloro-3-[1-{5-[3-(4-methyl-[1,4]diazepane-1-carbonyl)phenyl]furan-2-yl}propylidene]-1,3-dihydroindol-2-one

There total 7 articles about 5-chloro-3-[1-{5-[3-(4-methyl-[1,4]diazepane-1-carbonyl)phenyl]furan-2-yl}propylidene]-1,3-dihydroindol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 17630-75-0
5-chloro-indolin-2-one

: 1353858-95-3
1-{5-[3-(4-methyl[1,4]diazepane-1-carbonyl)phenyl]furan-2-yl}propan-1-one

: 1353859-03-6
5-chloro-3-[1-{5-[3-(4-methyl-[1,4]diazepane-1-carbonyl)phenyl]furan-2-yl}propylidene]-1,3-dihydroindol-2-one

Guidance literature:: 1-{5-[3-(4-methyl[1,4]diazepane-1-carbonyl)phenyl]furan-2-yl}propan-1-one; With titanium tetrachloride; In tetrahydrofuran; toluene; at -78 ℃; for 0.0166667h;

5-chloro-indolin-2-one; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; toluene; at -78 - 20 ℃; for 1h;
DOI:10.1021/ml200259q

Reference yield:

: 585-70-6
5-bromo-furan-2-carboxylic acid

: 1353859-03-6
5-chloro-3-[1-{5-[3-(4-methyl-[1,4]diazepane-1-carbonyl)phenyl]furan-2-yl}propylidene]-1,3-dihydroindol-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C

2.1: tetrahydrofuran / 16 h / 0 - 20 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,2-dimethoxyethane; water / 1.5 h / 80 °C

4.1: sodium hydroxide / ethanol; water / 16 h / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

6.1: titanium tetrachloride / tetrahydrofuran; toluene / 0.02 h / -78 °C

6.2: 1 h / -78 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; titanium tetrachloride; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; toluene;
DOI:10.1021/ml200259q

Reference yield:

: 1353858-93-1
3-(5-propionylfuran-2-yl)benzoic acid methyl ester

: 1353859-03-6
5-chloro-3-[1-{5-[3-(4-methyl-[1,4]diazepane-1-carbonyl)phenyl]furan-2-yl}propylidene]-1,3-dihydroindol-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol; water / 16 h / 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

3.1: titanium tetrachloride / tetrahydrofuran; toluene / 0.02 h / -78 °C

3.2: 1 h / -78 - 20 °C

With titanium tetrachloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1021/ml200259q