2-(3-CHLOROPROPYL)-2,5,5-TRIMETHYL-[1,3]-DIOXANE

Base Information

• Chemical Name: 2-(3-CHLOROPROPYL)-2,5,5-TRIMETHYL-[1,3]-DIOXANE
• CAS No.: 88128-57-8
• Molecular Formula: C10H19 Cl O2
• Molecular Weight: 206.713
• Mol file: 88128-57-8.mol

Synonyms:2-(3-CHLOROPROPYL)-2,5,5-TRIMETHYL-[1,3]-DIOXANE

Chemical Property of 2-(3-CHLOROPROPYL)-2,5,5-TRIMETHYL-[1,3]-DIOXANE

Chemical Property:

• Boiling Point: 247.7±15.0℃ (760 Torr)
• Flash Point: 67.1±15.6℃
• PSA: 18.46000
• Density: 0.980±0.06 g/cm3 (20 ºC 760 Torr)
• LogP: 2.79460
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-(3-Chloropropyl)-2,5,5-trimethyl-1,3-dioxane 95+% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 48/22-52/53
• Safety Statements: 23-25-36-61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-CHLOROPROPYL)-2,5,5-TRIMETHYL-[1,3]-DIOXANE

There total 2 articles about 2-(3-CHLOROPROPYL)-2,5,5-TRIMETHYL-[1,3]-DIOXANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-bis(4-oxopentyl 2',2'-dimethylpropylene ketal)piperidine (108818-51-5) → 5-chloro-2-pentanone 2',2'-dimethylpropylene ketal (88128-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 96.2 percent / 10percent HCl / tetrahydrofuran / 1 h

2: 2.) 4-Angstroem molecular sieves / 1.) p-toluenesulfonic acid / 1.) benzene, 6 h, reflux, 2.) benzene, 2 h, reflux

With hydrogenchloride; 4 A molecular sieve; toluene-4-sulfonic acid; In tetrahydrofuran;

DOI:10.1021/ja00250a030

Reference yield:

5-chloro-2-pentanone (5891-21-4) + 2,2-Dimethyl-1,3-propanediol (126-30-7) → 5-chloro-2-pentanone 2',2'-dimethylpropylene ketal (88128-57-8)

Guidance literature:

With 4 A molecular sieve; toluene-4-sulfonic acid; Yield given. Multistep reaction; 1.) benzene, 6 h, reflux, 2.) benzene, 2 h, reflux;

DOI:10.1021/ja00250a030

Reference yield:

5-chloro-2-pentanone 2',2'-dimethylpropylene ketal (88128-57-8) → 2-pentanone 2',2'-dimethylpropylene ketal (5421-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 85.6 percent / lithium / tetrahydrofuran; diethyl ether / 0.75 h / -25 °C

2: oxygen, water / benzene / 0 °C

With water; oxygen; lithium; In tetrahydrofuran; diethyl ether; benzene;

DOI:10.1021/ja00250a030

upstream raw materials:

5-chloro-2-pentanone

2,2-Dimethyl-1,3-propanediol

2,2-bis(4-oxopentyl 2',2'-dimethylpropylene ketal)piperidine

Downstream raw materials:

2-pentanone 2',2'-dimethylpropylene ketal

Refernces