Butyric acid (R)-1-butyryloxymethyl-2-{[(1S,2R,3R,4S,5S,6R)-3-(fluoromethyl-methoxy-phosphinoyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyloxy]-methoxy-phosphoryloxy}-ethyl ester

Base Information

Chemical Name:Butyric acid (R)-1-butyryloxymethyl-2-{[(1S,2R,3R,4S,5S,6R)-3-(fluoromethyl-methoxy-phosphinoyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyloxy]-methoxy-phosphoryloxy}-ethyl ester
CAS No.:876310-72-4
Molecular Formula:C₂₈H₅₃FO₁₉P₂
Molecular Weight:774.663
Hs Code.:

Butyric acid (R)-1-butyryloxymethyl-2-{[(1S,2R,3R,4S,5S,6R)-3-(fluoromethyl-methoxy-phosphinoyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyloxy]-methoxy-phosphoryloxy}-ethyl ester

Synonyms:Butyric acid (R)-1-butyryloxymethyl-2-{[(1S,2R,3R,4S,5S,6R)-3-(fluoromethyl-methoxy-phosphinoyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyloxy]-methoxy-phosphoryloxy}-ethyl ester

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Chemical Property of Butyric acid (R)-1-butyryloxymethyl-2-{[(1S,2R,3R,4S,5S,6R)-3-(fluoromethyl-methoxy-phosphinoyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyloxy]-methoxy-phosphoryloxy}-ethyl ester

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Technology Process of Butyric acid (R)-1-butyryloxymethyl-2-{[(1S,2R,3R,4S,5S,6R)-3-(fluoromethyl-methoxy-phosphinoyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyloxy]-methoxy-phosphoryloxy}-ethyl ester

There total 4 articles about Butyric acid (R)-1-butyryloxymethyl-2-{[(1S,2R,3R,4S,5S,6R)-3-(fluoromethyl-methoxy-phosphinoyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyloxy]-methoxy-phosphoryloxy}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 876310-80-4
Butyric acid (R)-1-butyryloxymethyl-2-(diisopropylamino-methoxy-phosphanyloxy)-ethyl ester

: 876310-66-6
Fluoromethyl-phosphonic acid (1S,2S,3S,4S,5R,6S)-3-hydroxy-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

: 876310-72-4
Butyric acid (R)-1-butyryloxymethyl-2-{[(1S,2R,3R,4S,5S,6R)-3-(fluoromethyl-methoxy-phosphinoyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyloxy]-methoxy-phosphoryloxy}-ethyl ester

Guidance literature:: Butyric acid (R)-1-butyryloxymethyl-2-(diisopropylamino-methoxy-phosphanyloxy)-ethyl ester; Fluoromethyl-phosphonic acid (1S,2S,3S,4S,5R,6S)-3-hydroxy-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester; With 1H-tetrazole; In tetrahydrofuran; at 20 ℃; for 16h;

With tetrabutylammonium periodite; In tetrahydrofuran; at -20 - 20 ℃; for 1.5h;
DOI:10.1021/ja0554716

Reference yield:

: 876310-64-4
Fluoromethyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

: 876310-72-4
Butyric acid (R)-1-butyryloxymethyl-2-{[(1S,2R,3R,4S,5S,6R)-3-(fluoromethyl-methoxy-phosphinoyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyloxy]-methoxy-phosphoryloxy}-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 56 percent / tetrabutylammonium fluoride trihydrate; AcOH / tetrahydrofuran / 12 h / 20 °C

2.1: 1H-tetrazole / tetrahydrofuran / 16 h / 20 °C

2.2: 70 percent / n-Bu₄NIO₄ / tetrahydrofuran / 1.5 h / -20 - 20 °C

With 1H-tetrazole; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran;
DOI:10.1021/ja0554716

Reference yield:

: 30403-46-4
1,2-dibutanoyl-sn-glycerol

: 876310-72-4
Butyric acid (R)-1-butyryloxymethyl-2-{[(1S,2R,3R,4S,5S,6R)-3-(fluoromethyl-methoxy-phosphinoyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyloxy]-methoxy-phosphoryloxy}-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: DIPEA / CH₂Cl₂

2.1: 1H-tetrazole / tetrahydrofuran / 16 h / 20 °C

2.2: 70 percent / n-Bu₄NIO₄ / tetrahydrofuran / 1.5 h / -20 - 20 °C

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja0554716