Fluoromethyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

Base Information

Chemical Name:Fluoromethyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester
CAS No.:876310-64-4
Molecular Formula:C₃₂H₅₀FO₁₂PSi
Molecular Weight:704.799
Hs Code.:

Fluoromethyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

Synonyms:Fluoromethyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

Suppliers and Price of Fluoromethyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Fluoromethyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Fluoromethyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

There total 1 articles about Fluoromethyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl (fluoromethyl)phosphonate chloride

: 165689-84-9
1D-1-O-(tert-butyldiphenylsilyl)-2,4,5,6-O-tetrakis(methoxymethylene)-myo-inositol

: 876310-64-4
Fluoromethyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

Guidance literature:: With potassium tert-butylate; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ja0554716

Reference yield: 56.0%

: 876310-64-4
Fluoromethyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

: 876310-66-6
Fluoromethyl-phosphonic acid (1S,2S,3S,4S,5R,6S)-3-hydroxy-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1021/ja0554716

Reference yield:

: 876310-64-4
Fluoromethyl-phosphonic acid (1R,2S,3S,4R,5R,6S)-3-(tert-butyl-diphenyl-silanyloxy)-2,4,5,6-tetrakis-methoxymethoxy-cyclohexyl ester methyl ester

: Butyric acid (R)-1-butyryloxymethyl-2-{[(1S,2R,3R,4S,5S,6R)-3-(fluoromethyl-hydroxy-phosphinoyloxy)-2,4,5,6-tetrahydroxy-cyclohexyloxy]-hydroxy-phosphoryloxy}-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 56 percent / tetrabutylammonium fluoride trihydrate; AcOH / tetrahydrofuran / 12 h / 20 °C

2.1: 1H-tetrazole / tetrahydrofuran / 16 h / 20 °C

2.2: 70 percent / n-Bu₄NIO₄ / tetrahydrofuran / 1.5 h / -20 - 20 °C

3.1: TMS-Br / CH₂Cl₂ / 0.5 h / 20 °C

3.2: H₂O / methanol / 0.5 h / 20 °C

3.3: 68 percent / ethanethiol / 1 h / 20 °C

With 1H-tetrazole; trimethylsilyl bromide; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja0554716