tert-butyl 2-[(6-{[2-(methoxycarbonyl)phenyl]amino}-6-oxohexanoyl)amino]-4-phenylthiophene-3-carboxylate

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Chemical Name:tert-butyl 2-[(6-{[2-(methoxycarbonyl)phenyl]amino}-6-oxohexanoyl)amino]-4-phenylthiophene-3-carboxylate
CAS No.:1103928-78-4
Molecular Formula:C₂₉H₃₂N₂O₆S
Molecular Weight:536.649
Hs Code.:

Synonyms:tert-butyl 2-[(6-{[2-(methoxycarbonyl)phenyl]amino}-6-oxohexanoyl)amino]-4-phenylthiophene-3-carboxylate

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Chemical Property of tert-butyl 2-[(6-{[2-(methoxycarbonyl)phenyl]amino}-6-oxohexanoyl)amino]-4-phenylthiophene-3-carboxylate

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Technology Process of tert-butyl 2-[(6-{[2-(methoxycarbonyl)phenyl]amino}-6-oxohexanoyl)amino]-4-phenylthiophene-3-carboxylate

There total 6 articles about tert-butyl 2-[(6-{[2-(methoxycarbonyl)phenyl]amino}-6-oxohexanoyl)amino]-4-phenylthiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1103928-76-2
6-{[3-(tert-butoxycarbonyl)-4-phenylthiophen-2-yl]amino}-6-oxohexanoic acid

: 134-20-3
2-carbomethoxyaniline

: 1103928-78-4
tert-butyl 2-[(6-{[2-(methoxycarbonyl)phenyl]amino}-6-oxohexanoyl)amino]-4-phenylthiophene-3-carboxylate

Guidance literature:: 6-{[3-(tert-butoxycarbonyl)-4-phenylthiophen-2-yl]amino}-6-oxohexanoic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at 0 ℃; for 1h;

2-carbomethoxyaniline; In tetrahydrofuran; for 1h;

Reference yield:

: 944578-51-2
tert-butyl 2-amino-4-phenylthiophene-3-carboxylate

: 1103928-78-4
tert-butyl 2-[(6-{[2-(methoxycarbonyl)phenyl]amino}-6-oxohexanoyl)amino]-4-phenylthiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1,2-dimethoxyethane / 1 h / 0 - 20 °C

2: water; sodium hydroxide / tetrahydrofuran / 2.5 h / 60 °C

3: triethylamine / tetrahydrofuran / 1 h / 0 °C

4: tetrahydrofuran / 16 h / 0 - 20 °C

With water; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1248/cpb.59.215

Reference yield:

: 35444-44-1
methyl adipoyl chloride

: 1103928-78-4
tert-butyl 2-[(6-{[2-(methoxycarbonyl)phenyl]amino}-6-oxohexanoyl)amino]-4-phenylthiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1,2-dimethoxyethane / 1 h / 0 - 20 °C

2: water; sodium hydroxide / tetrahydrofuran / 2.5 h / 60 °C

3: triethylamine / tetrahydrofuran / 1 h / 0 °C

4: tetrahydrofuran / 16 h / 0 - 20 °C

With water; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1248/cpb.59.215