2-[(1-tert-butyloxycarbonyl)piperidin-4-yl]-3-cyano-4-(4,4-difluorocyclohexyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline

Base Information

Chemical Name:2-[(1-tert-butyloxycarbonyl)piperidin-4-yl]-3-cyano-4-(4,4-difluorocyclohexyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline
CAS No.:1354495-91-2
Molecular Formula:C₂₈H₃₉F₂N₃O₃
Molecular Weight:503.633
Hs Code.:

Synonyms:2-[(1-tert-butyloxycarbonyl)piperidin-4-yl]-3-cyano-4-(4,4-difluorocyclohexyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline

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Chemical Property of 2-[(1-tert-butyloxycarbonyl)piperidin-4-yl]-3-cyano-4-(4,4-difluorocyclohexyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline

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Technology Process of 2-[(1-tert-butyloxycarbonyl)piperidin-4-yl]-3-cyano-4-(4,4-difluorocyclohexyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline

There total 3 articles about 2-[(1-tert-butyloxycarbonyl)piperidin-4-yl]-3-cyano-4-(4,4-difluorocyclohexyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 265108-36-9
4,4-difluorocyclohexane carboxyaldehyde

: 1354495-90-1
4-(1-amino-2-cyanoethenyl)piperidin-1-carboxylic acid tert-butyl ester

: 126-81-8
dimedone

: 1354495-91-2
2-[(1-tert-butyloxycarbonyl)piperidin-4-yl]-3-cyano-4-(4,4-difluorocyclohexyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline

Guidance literature:: 4,4-difluorocyclohexane carboxyaldehyde; 4-(1-amino-2-cyanoethenyl)piperidin-1-carboxylic acid tert-butyl ester; In toluene; at 100 ℃; for 0.166667h;

dimedone; In toluene; for 15h; Reflux;

Reference yield:

: 178312-47-5
ethyl 4,4-difluorocyclohexane-1-carboxylate

: 1354495-91-2
2-[(1-tert-butyloxycarbonyl)piperidin-4-yl]-3-cyano-4-(4,4-difluorocyclohexyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / toluene / 0.5 h / -60 - -55 °C

2.1: toluene / 0.17 h / 100 °C

2.2: 15 h / Reflux

With diisobutylaluminium hydride; In toluene;

Reference yield:

: 91419-52-2
1-tert-butoxycarbonyl-4-cyanopiperidine

: 1354495-91-2
2-[(1-tert-butyloxycarbonyl)piperidin-4-yl]-3-cyano-4-(4,4-difluorocyclohexyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; ethylbenzene; n-heptane / 3 h / Cooling with acetone-dry ice

1.2: 24 h / 20 °C / Cooling with acetone-dry ice

2.1: toluene / 0.17 h / 100 °C

2.2: 15 h / Reflux

With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; toluene;