4-{[(4-cyanophenyl)(1H-imidazol-1-yl)amino]methyl}-3-fluorophenylsulfamate

Base Information

Chemical Name:4-{[(4-cyanophenyl)(1H-imidazol-1-yl)amino]methyl}-3-fluorophenylsulfamate
CAS No.:1472067-99-4
Molecular Formula:C₁₇H₁₄FN₅O₃S
Molecular Weight:387.394
Hs Code.:

Synonyms:4-{[(4-cyanophenyl)(1H-imidazol-1-yl)amino]methyl}-3-fluorophenylsulfamate

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Chemical Property of 4-{[(4-cyanophenyl)(1H-imidazol-1-yl)amino]methyl}-3-fluorophenylsulfamate

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Technology Process of 4-{[(4-cyanophenyl)(1H-imidazol-1-yl)amino]methyl}-3-fluorophenylsulfamate

There total 9 articles about 4-{[(4-cyanophenyl)(1H-imidazol-1-yl)amino]methyl}-3-fluorophenylsulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1472068-50-0
4-[(2-fluoro-4-hydroxybenzyl)(1H-imidazol-1-yl)amino]benzonitrile

: 1472067-99-4
4-{[(4-cyanophenyl)(1H-imidazol-1-yl)amino]methyl}-3-fluorophenylsulfamate

Guidance literature:: With sulphamoyl chloride; In N,N-dimethyl acetamide; at 0 - 20 ℃;
DOI:10.1002/cmdc.201300015

Reference yield:

: 197507-22-5
methyl 2-fluoro-4-hydroxybenzoate

: 1472067-99-4
4-{[(4-cyanophenyl)(1H-imidazol-1-yl)amino]methyl}-3-fluorophenylsulfamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.75 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: thionyl chloride / dichloromethane / 2 h

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

4.2: 18 h

5.1: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran; methanol / 20 °C

6.1: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With lithium aluminium tetrahydride; thionyl chloride; 5%-palladium/activated carbon; sulphamoyl chloride; hydrogen; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201300015

Reference yield:

: 96740-92-0
3-fluoro-4-(hydroxymethyl)phenol

: 1472067-99-4
4-{[(4-cyanophenyl)(1H-imidazol-1-yl)amino]methyl}-3-fluorophenylsulfamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: thionyl chloride / dichloromethane / 2 h

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

3.2: 18 h

4.1: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran; methanol / 20 °C

5.1: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With thionyl chloride; 5%-palladium/activated carbon; sulphamoyl chloride; hydrogen; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201300015