4-(8-benzyloxy-7-methoxy-2-methyl-2H-pyrazolo[3,4-c]quinolin-1-yl)benzonitrile

Base Information

Chemical Name:4-(8-benzyloxy-7-methoxy-2-methyl-2H-pyrazolo[3,4-c]quinolin-1-yl)benzonitrile
CAS No.:1353635-94-5
Molecular Formula:C₂₆H₂₀N₄O₂
Molecular Weight:420.47
Hs Code.:

Synonyms:4-(8-benzyloxy-7-methoxy-2-methyl-2H-pyrazolo[3,4-c]quinolin-1-yl)benzonitrile

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Chemical Property of 4-(8-benzyloxy-7-methoxy-2-methyl-2H-pyrazolo[3,4-c]quinolin-1-yl)benzonitrile

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Technology Process of 4-(8-benzyloxy-7-methoxy-2-methyl-2H-pyrazolo[3,4-c]quinolin-1-yl)benzonitrile

There total 6 articles about 4-(8-benzyloxy-7-methoxy-2-methyl-2H-pyrazolo[3,4-c]quinolin-1-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1353636-04-0
4-(8-benzyloxy-7-methoxy-3H-pyrazolo[3,4-c]quinolin-1-yl)benzonitrile

: 74-88-4
methyl iodide

: 1353635-93-4
4-(8-benzyloxy-7-methoxy-3-methyl-3H-pyrazolo[3,4-c]quinolin-1-yl)benzonitrile

: 1353635-94-5
4-(8-benzyloxy-7-methoxy-2-methyl-2H-pyrazolo[3,4-c]quinolin-1-yl)benzonitrile

Guidance literature:: With potassium carbonate; In water; N,N-dimethyl-formamide; isopropyl alcohol; at 20 ℃; for 18h;

Reference yield:

: 1353636-03-9
4-(3-amino-6-benzyloxy-7-methoxyquinoline-4-carbonyl)benzonitrile

: 1353635-93-4
4-(8-benzyloxy-7-methoxy-3-methyl-3H-pyrazolo[3,4-c]quinolin-1-yl)benzonitrile

: 1353635-94-5
4-(8-benzyloxy-7-methoxy-2-methyl-2H-pyrazolo[3,4-c]quinolin-1-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h

1.2: 1 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide; water; isopropyl alcohol / 18 h / 20 °C

With hydrogenchloride; potassium carbonate; sodium nitrite; In water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1353636-05-1,909912-11-4
6-benzyloxy-7-methoxy-3-nitro-1H-quinolin-4-one

: 1353635-93-4
4-(8-benzyloxy-7-methoxy-3-methyl-3H-pyrazolo[3,4-c]quinolin-1-yl)benzonitrile

: 1353635-94-5
4-(8-benzyloxy-7-methoxy-2-methyl-2H-pyrazolo[3,4-c]quinolin-1-yl)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / N,N-dimethyl-formamide / 0.5 h / 100 °C

2.1: sodium hydride; hydrogenchloride / tetrahydrofuran; paraffin oil / Cooling with ice; Inert atmosphere

2.2: 2 h / 20 °C

3.1: potassium permanganate / water / 2 h / Reflux

4.1: hydrogenchloride; iron / methanol / 18 h / 66 °C

5.1: hydrogenchloride; sodium nitrite / water / 0.5 h

5.2: 1 h / 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide; water; isopropyl alcohol / 18 h / 20 °C

With hydrogenchloride; potassium permanganate; iron; sodium hydride; potassium carbonate; sodium nitrite; trichlorophosphate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; paraffin oil;