N-p-toluenesulfonyl-2-chloromethylindole

Base Information

Chemical Name:N-p-toluenesulfonyl-2-chloromethylindole
CAS No.:1617530-91-2
Molecular Formula:C₁₆H₁₄ClNO₂S
Molecular Weight:319.812
Hs Code.:

Synonyms:N-p-toluenesulfonyl-2-chloromethylindole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-p-toluenesulfonyl-2-chloromethylindole

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Technology Process of N-p-toluenesulfonyl-2-chloromethylindole

There total 4 articles about N-p-toluenesulfonyl-2-chloromethylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: [1-(toluene-4-sulfonyl)-indol-2-yl]-methanol

: 1617530-91-2
N-p-toluenesulfonyl-2-chloromethylindole

Guidance literature:: With N-chloro-succinimide; triphenylphosphine; In dichloromethane; at 0 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1039/c4cc03904a

Reference yield:

: 3770-50-1,117770-52-2
2-carbethoxyindole

: 1617530-91-2
N-p-toluenesulfonyl-2-chloromethylindole

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / N,N-dimethyl-formamide / 12.5 h / 0 - 20 °C / Inert atmosphere

2: diisobutylaluminium hydride / dichloromethane; cyclohexane / 14 h / -78 - 20 °C / Inert atmosphere

3: N-chloro-succinimide; triphenylphosphine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

With N-chloro-succinimide; diisobutylaluminium hydride; triphenylphosphine; In dichloromethane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1039/c4cc03904a

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1617530-91-2
N-p-toluenesulfonyl-2-chloromethylindole

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / N,N-dimethyl-formamide / 12.5 h / 0 - 20 °C / Inert atmosphere

2: diisobutylaluminium hydride / dichloromethane; cyclohexane / 14 h / -78 - 20 °C / Inert atmosphere

3: N-chloro-succinimide; triphenylphosphine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

With N-chloro-succinimide; diisobutylaluminium hydride; triphenylphosphine; In dichloromethane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1039/c4cc03904a