ethyl 2-{[(tert-butoxycarbonyl)(3-phenylpropyl)aminomethyl]methyl}-1,3-thiazole-4-carboxylate

Base Information

Chemical Name:ethyl 2-{[(tert-butoxycarbonyl)(3-phenylpropyl)aminomethyl]methyl}-1,3-thiazole-4-carboxylate
CAS No.:1282549-56-7
Molecular Formula:C₂₁H₂₈N₂O₄S
Molecular Weight:404.53
Hs Code.:

Synonyms:ethyl 2-{[(tert-butoxycarbonyl)(3-phenylpropyl)aminomethyl]methyl}-1,3-thiazole-4-carboxylate

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Chemical Property of ethyl 2-{[(tert-butoxycarbonyl)(3-phenylpropyl)aminomethyl]methyl}-1,3-thiazole-4-carboxylate

Chemical Property:

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Technology Process of ethyl 2-{[(tert-butoxycarbonyl)(3-phenylpropyl)aminomethyl]methyl}-1,3-thiazole-4-carboxylate

There total 3 articles about ethyl 2-{[(tert-butoxycarbonyl)(3-phenylpropyl)aminomethyl]methyl}-1,3-thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6436-59-5
ethyl 2-methylthiazole-4-carboxylate

: 1282549-56-7
ethyl 2-{[(tert-butoxycarbonyl)(3-phenylpropyl)aminomethyl]methyl}-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane; water / 1.67 h / Irradiation; Reflux

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate / methanol; acetonitrile / 1 h / 20 °C / Cooling with ice

3.1: tetrahydrofuran / 2 h / 20 °C / Cooling with ice

With N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; water; acetonitrile;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1282549-53-4
ethyl 2-{[(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxylate

: 1282549-56-7
ethyl 2-{[(tert-butoxycarbonyl)(3-phenylpropyl)aminomethyl]methyl}-1,3-thiazole-4-carboxylate

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 2h; Cooling with ice;

Reference yield:

: 78502-71-3
ethyl 2-(bromomethyl)-1,3-thiazole-4-carboxylate

: 1282549-56-7
ethyl 2-{[(tert-butoxycarbonyl)(3-phenylpropyl)aminomethyl]methyl}-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol; acetonitrile / 1 h / 20 °C / Cooling with ice

2: tetrahydrofuran / 2 h / 20 °C / Cooling with ice

With potassium carbonate; In tetrahydrofuran; methanol; acetonitrile;