methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-cyclopropyl-1H-benzimidazole-7-carboxylate

Base Information

Chemical Name:methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-cyclopropyl-1H-benzimidazole-7-carboxylate
CAS No.:147404-04-4
Molecular Formula:C₂₆H₂₁N₃O₂
Molecular Weight:407.472
Hs Code.:

Synonyms:methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-cyclopropyl-1H-benzimidazole-7-carboxylate

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Chemical Property of methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-cyclopropyl-1H-benzimidazole-7-carboxylate

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Technology Process of methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-cyclopropyl-1H-benzimidazole-7-carboxylate

There total 11 articles about methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-cyclopropyl-1H-benzimidazole-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 136304-78-4
methyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]benzoate

: 147404-04-4
methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-cyclopropyl-1H-benzimidazole-7-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm00067a016

Reference yield:

: C₂₆H₂₃N₃O₃

: 147404-04-4
methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-cyclopropyl-1H-benzimidazole-7-carboxylate

Guidance literature:: C₂₆H₂₃N₃O₃; With hydrogenchloride; In ethanol; water; at 80 ℃; for 5h;

With sodium hydroxide; In ethanol; water;

Reference yield:

: 21606-04-2
methyl 2-carboxy-3-nitrobenzoate

: 147404-04-4
methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-cyclopropyl-1H-benzimidazole-7-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂, DMF / toluene / 0.5 h / Heating

2: NaN₃ / acetone; H₂O / 1 h

3: 1.5 h / Heating

4: 85 percent / K₂CO₃ / acetonitrile / 4 h / Heating

5: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature

6: 1.) FeCl₃*6H₂O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h

7: 77 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; thionyl chloride; sodium azide; potassium carbonate; pyrographite; hydrazine hydrate; triethylamine; N,N-dimethyl-formamide; In dichloromethane; water; ethyl acetate; acetone; toluene; acetonitrile;
DOI:10.1021/jm00067a016