(2S,2'S)-dimethyl-1,1'-((2R,2'R)-2,2'-((2-iodo-1,3-phenylene)bis(oxy))bis(propanoyl))bis(pyrrolidine-2-carboxylate)

Base Information

Chemical Name:(2S,2'S)-dimethyl-1,1'-((2R,2'R)-2,2'-((2-iodo-1,3-phenylene)bis(oxy))bis(propanoyl))bis(pyrrolidine-2-carboxylate)
CAS No.:1611494-85-9
Molecular Formula:C₂₄H₃₁IN₂O₈
Molecular Weight:602.423
Hs Code.:

Synonyms:(2S,2'S)-dimethyl-1,1'-((2R,2'R)-2,2'-((2-iodo-1,3-phenylene)bis(oxy))bis(propanoyl))bis(pyrrolidine-2-carboxylate)

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Chemical Property of (2S,2'S)-dimethyl-1,1'-((2R,2'R)-2,2'-((2-iodo-1,3-phenylene)bis(oxy))bis(propanoyl))bis(pyrrolidine-2-carboxylate)

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Technology Process of (2S,2'S)-dimethyl-1,1'-((2R,2'R)-2,2'-((2-iodo-1,3-phenylene)bis(oxy))bis(propanoyl))bis(pyrrolidine-2-carboxylate)

There total 4 articles about (2S,2'S)-dimethyl-1,1'-((2R,2'R)-2,2'-((2-iodo-1,3-phenylene)bis(oxy))bis(propanoyl))bis(pyrrolidine-2-carboxylate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: (2R,2'R)-2,2'-((2-iodo-1,3-phenylene)bis(oxy))dipropanoyl chloride

: 2133-40-6
L-proline methyl ester monohydrochloride

: 1611494-85-9
(2S,2'S)-dimethyl-1,1'-((2R,2'R)-2,2'-((2-iodo-1,3-phenylene)bis(oxy))bis(propanoyl))bis(pyrrolidine-2-carboxylate)

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1002/anie.201309967

Reference yield: 85.0%

: 1226896-33-8
(2R,2′R)-2,2′-((2-iodo-1,3-phenylene)bis(oxy))dipropanoic acid

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 1611494-85-9
(2S,2'S)-dimethyl-1,1'-((2R,2'R)-2,2'-((2-iodo-1,3-phenylene)bis(oxy))bis(propanoyl))bis(pyrrolidine-2-carboxylate)

Guidance literature:: (2R,2′R)-2,2′-((2-iodo-1,3-phenylene)bis(oxy))dipropanoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; Inert atmosphere;

methyl (2S)-pyrrolidine carboxylate; In dichloromethane; at 0 - 20 ℃; Alkaline conditions;
DOI:10.1021/acs.orglett.6b02816

Reference yield:

: 41046-67-7
2-iodoresorcinol

: 1611494-85-9
(2S,2'S)-dimethyl-1,1'-((2R,2'R)-2,2'-((2-iodo-1,3-phenylene)bis(oxy))bis(propanoyl))bis(pyrrolidine-2-carboxylate)

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; toluene / 6 h / 0 - 20 °C

2.1: sodium hydroxide; methanol / tetrahydrofuran / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / Inert atmosphere

3.2: 0 - 20 °C / Alkaline conditions

With methanol; oxalyl dichloride; di-isopropyl azodicarboxylate; N,N-dimethyl-formamide; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/acs.orglett.6b02816