O^1.4-ethyl dihydrogen N^2.1,N^6.1-di-Cbz-L-lysylglycyl-α-L-aspartyl-L-glutamate

Base Information

• Chemical Name: O^1.4-ethyl dihydrogen N^2.1,N^6.1-di-Cbz-L-lysylglycyl-α-L-aspartyl-L-glutamate
• CAS No.: 165282-31-5
• Molecular Formula: C₃₅H₄₅N₅O₁₃
• Molecular Weight: 743.768

Synonyms:O^1.4-ethyl dihydrogen N^2.1,N^6.1-di-Cbz-L-lysylglycyl-α-L-aspartyl-L-glutamate

Chemical Property of O^1.4-ethyl dihydrogen N^2.1,N^6.1-di-Cbz-L-lysylglycyl-α-L-aspartyl-L-glutamate

Chemical Property:

Purity/Quality:

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Technology Process of O^1.4-ethyl dihydrogen N^2.1,N^6.1-di-Cbz-L-lysylglycyl-α-L-aspartyl-L-glutamate

There total 5 articles about O^1.4-ethyl dihydrogen N^2.1,N^6.1-di-Cbz-L-lysylglycyl-α-L-aspartyl-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

O4.3,O5.4-diallyl O1.4-ethyl N2.1,N6.1-di-Cbz-L-lysylglycyl-α-L-aspartyl-L-glutamate (165282-30-4) → O1.4-ethyl dihydrogen N2.1,N6.1-di-Cbz-L-lysylglycyl-α-L-aspartyl-L-glutamate (165282-31-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium 2-ethylhexanoate; triphenylphosphine; In dichloromethane; ethyl acetate; at 20 ℃; for 4h;

Reference yield:

Nα,Nξ-di-Cbz-L-lysylglycine ethyl ester (13567-34-5) → O1.4-ethyl dihydrogen N2.1,N6.1-di-Cbz-L-lysylglycyl-α-L-aspartyl-L-glutamate (165282-31-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / ethanol / 2 h / 37 °C / papaya protease IV, CHES buffer, EDTA, dithiothreitol

2: 76 percent / 40 h / 37 °C / immobilized subtilisin

3: 96 percent / potassium 2-ethylhexanoate, PPh₃, Pd(PPh₃)4 / CH₂Cl₂; ethyl acetate / 4 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium 2-ethylhexanoate; triphenylphosphine; In ethanol; dichloromethane; ethyl acetate;

Reference yield:

Nα,Nξ-di-Cbz-L-lysine ethyl ester (83173-67-5) → O1.4-ethyl dihydrogen N2.1,N6.1-di-Cbz-L-lysylglycyl-α-L-aspartyl-L-glutamate (165282-31-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / 1.) NaOH/EtOH, K₂CO₃, KHCO₃, / ethanol / 40 h / 37 °C / chymopapain, CHES buffer, EDTA, dithiothreitol

2: 84 percent / ethanol / 2 h / 37 °C / papaya protease IV, CHES buffer, EDTA, dithiothreitol

3: 76 percent / 40 h / 37 °C / immobilized subtilisin

4: 96 percent / potassium 2-ethylhexanoate, PPh₃, Pd(PPh₃)4 / CH₂Cl₂; ethyl acetate / 4 h / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; potassium 2-ethylhexanoate; potassium carbonate; potassium hydrogencarbonate; triphenylphosphine; In ethanol; dichloromethane; ethyl acetate;

upstream raw materials:

O^4.3,O^5.4-diallyl O^1.4-ethyl N^2.1,N^6.1-di-Cbz-L-lysylglycyl-α-L-aspartyl-L-glutamate

N_α,N_ξ-di-Cbz-L-lysylglycine ethyl ester

N_α,N_ξ-di-Cbz-L-lysine ethyl ester

O^1.3,O^4.3-diallyl N^2.1,N^6.1-di-Cbz-L-lysylglycyl-L-aspartate

Downstream raw materials:

O^5.5-ethyl dihydrogen N^2.1,N^6.1-di-Cbz-L-lysylglycyl-α-L-aspartyl-α-L-glutamyl-α-L-glutamyl-L-seryl-L-leucyl-L-alaninamide

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