13567-34-5Relevant academic research and scientific papers
Reactivity of Aromatic o-Hydroxy Oximes. II. The Use of Esters of Aromatic o-Hydroxy Oximes in Peptide Synthesis
Hayashi, Ikuo,Shimizu, Kiyoshi
, p. 3197 - 3198 (1983)
Esters of N-protected amino acids with o-hydroxybenzaldehyde oxime, o-hydroxyacetophenone oxime, o-hydroxybenzophenone oxime, and their 5-Cl and 5-NO2 derivatives were prepared by several methods.Various dipeptide derivatives with high purity were obtaine
Pilot-scale enzymatic synthesis of bioactive oligopeptides in eutectic-based media
Gill, Iqbal,Valivety, Rao
, p. 684 - 691 (2002)
The bioactive peptide precursors Nα-Cbz-L-Lys(Nζ-Cbz)-Gly-OEt (1), Nα-Cbz-L-Lys(Nζ-Cbz)-Gly-L-Asp(OAll)-OAll (2), and Nα-Cbz-L-Lys(Nζ-Cbz)-Gly-L-Asp(OAll)-L-Glu (OAll)OEt (3) were synthesiz
Enzymatic Synthesis of the Delicious Peptide Fragments in Eutectic Mixtures
Jorba, Xavier,Gill, Iqbal,Vulfson, Evgeny N.
, p. 2536 - 2541 (2007/10/03)
The feasibility of flavor peptide production has been investigated using proteases in liquid/semiliquid eutectic mixtures comprised of the substrates together with small amounts of water and alcohols (19-24percent w/w).The three functional fragments of the so-called "Delicious Octapeptide", L-Lys-Gly, L-Asp-Glu-Glu, and L-Ser-Leu-Ala, were obtained in good yields without any requirement for the regioselective side-chain protection of multifunctional amino acids.The peptides were synthesized on a preparative scale in overall yields of 29-77percent and were fully characterized.Keywords: Delicious Peptide; food peptides; flavor peptides; enzymatic peptide synthesis; eutectic mixtures; proteases; adjuvants
Enzymatic oligopeptide synthesis using a minimal protection strategy: Sequential assembly of a growing oligopeptide chain
Gill, Iqbal,López-Fandi?o, Rosina,Vulfson, Evgeny
, p. 6175 - 6177 (2007/10/02)
An approach to the enzymatic synthesis of oligopeptides is described which relies upon the selectivities of the enzymes employed rather than on the differential protection of the substrates for obtaining the desired sequences. Serine and cysteine protease
3-O--HYDROXY-2-PHENYLINDENONES, PREPARATION AND USE IN THE SYNTHESIS OF PEPTIDES
Mincev, Stoyan,Derdowska, Izabela,Kupryszewski, Gotfryd
, p. 443 - 452 (2007/10/02)
Several 3-O--hydroxy-2-phenylindenones were obtained and used in the synthesis of peptides.Synthesis of Leu-enkephalin was carried out.
