Technology Process of 1,2-dimethyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazole
There total 6 articles about 1,2-dimethyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
C40H40Cl3N3Pd; oxygen; potassium carbonate; Trimethylacetic acid;
In
N,N-dimethyl acetamide;
at 130 ℃;
for 12h;
under 760.051 Torr;
regioselective reaction;
DOI:10.1021/acs.organomet.6b00391
- Guidance literature:
-
With
C48H42Cl4N8O2Pd2; potassium carbonate; Trimethylacetic acid;
In
N,N-dimethyl acetamide;
at 130 ℃;
for 18h;
regioselective reaction;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/adsc.201901189
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide; potassium carbonate / ethyl acetate / 1.5 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran / 0.75 h / -100 - -80 °C / Inert atmosphere
2.2: -80 - 20 °C / Inert atmosphere
3.1: palladium diacetate; triphenylphosphine; potassium carbonate / N,N-dimethyl acetamide / 140 °C
With
N-Bromosuccinimide; n-butyllithium; palladium diacetate; potassium carbonate; triphenylphosphine;
In
tetrahydrofuran; N,N-dimethyl acetamide; ethyl acetate;
DOI:10.1002/adsc.201500888
