p-nitrobenzyl (2S,4R)-N-Boc-4,2'-dideuterio-4-(Z)-propenylprolinate

Base Information

• Chemical Name: p-nitrobenzyl (2S,4R)-N-Boc-4,2'-dideuterio-4-(Z)-propenylprolinate
• CAS No.: 804549-21-1
• Molecular Formula: C₂₀H₂₆N₂O₆
• Molecular Weight: 392.42
• Mol file: 804549-21-1.mol

Synonyms:p-nitrobenzyl (2S,4R)-N-Boc-4,2'-dideuterio-4-(Z)-propenylprolinate

Chemical Property of p-nitrobenzyl (2S,4R)-N-Boc-4,2'-dideuterio-4-(Z)-propenylprolinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-nitrobenzyl (2S,4R)-N-Boc-4,2'-dideuterio-4-(Z)-propenylprolinate

There total 2 articles about p-nitrobenzyl (2S,4R)-N-Boc-4,2'-dideuterio-4-(Z)-propenylprolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2S,4R)-N-Boc-4,2'-Dideuterio-4-(Z)-propenylproline (804549-36-8) + 1-bromomethyl-4-nitro-benzene (100-11-8) → p-nitrobenzyl (2S,4R)-N-Boc-4,2'-dideuterio-4-(Z)-propenylprolinate (804549-21-1)

Guidance literature:

With potassium carbonate; In acetonitrile; at 70 ℃; for 3h;

DOI:10.1002/chem.200400406

Reference yield:

(2S,4R)-N-Boc-4,2'-dideuterio-4-(Z)-propenylprolinol → p-nitrobenzyl (2S,4R)-N-Boc-4,2'-dideuterio-4-(Z)-propenylprolinate (804549-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Jones reagent / acetone / 2 h / 4 °C

2: 93 percent / K₂CO₃ / acetonitrile / 3 h / 70 °C

With jones reagent; potassium carbonate; In acetone; acetonitrile;

DOI:10.1002/chem.200400406

Reference yield: 83.0%

p-nitrobenzyl (2S,4R)-N-Boc-4,2'-dideuterio-4-(Z)-propenylprolinate (804549-21-1) → p-nitrobenzyl (2S,4R)-4,2'-dideuterio-4-(Z)-propenylprolinate hydrochloride

Guidance literature:

With hydrogenchloride; In diethyl ether; for 2h;

DOI:10.1002/chem.200400406

upstream raw materials:

(2S,4R)-N-Boc-4,2'-Dideuterio-4-(Z)-propenylproline

1-bromomethyl-4-nitro-benzene