3-(1-{4-[2-(Dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl)phenol

Base Information

Chemical Name:3-(1-{4-[2-(Dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl)phenol
CAS No.:83647-29-4
Molecular Formula:C26H29 N O2
Molecular Weight:387.522
Hs Code.:2922509090
DSSTox Substance ID:DTXSID20274463
Mol file:83647-29-4.mol

Synonyms:83647-29-4;3-[(E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol;DTXSID20274463;3-[(1E)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol;3-(1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl)phenol;FT-0625612

Suppliers and Price of 3-(1-{4-[2-(Dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl)phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 3-(1-{4-[2-(Dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl)phenol

Chemical Property:

PSA：32.70000
LogP:5.70170
XLogP3:6.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:387.219829168
Heavy Atom Count:29
Complexity:501

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(=C(C1=CC=C(C=C1)OCCN(C)C)C2=CC(=CC=C2)O)C3=CC=CC=C3

Technology Process of 3-(1-{4-[2-(Dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl)phenol

There total 14 articles about 3-(1-{4-[2-(Dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 2,2-dimethyl-propionic acid 3-{1-[4-(2-dimethylamino-ethoxy)-phenyl]-2-phenyl-but-3-enyl}-phenyl ester

: 82413-20-5
Droloxifene

: 83647-29-4
1-(4-[2-dimethylaminoethoxy]phenyl)-1-(3-hydroxyphenyl)-2-phenylbut-1-ene

Guidance literature:: With potassium tert-butylate; In dimethyl sulfoxide; at 50 ℃; for 2h;
DOI:10.1016/j.tetlet.2005.12.117

Reference yield: 49.0%

: 4-[4-(2-dimethylaminoethoxy)phenyl]-4-(3-hydroxyphenyl)-3-phenylbut-1-ene

: 82413-20-5
Droloxifene

: 83647-29-4
1-(4-[2-dimethylaminoethoxy]phenyl)-1-(3-hydroxyphenyl)-2-phenylbut-1-ene

Guidance literature:: With potassium tert-butylate; In dimethyl sulfoxide; at 50 ℃; for 2h;
DOI:10.1016/j.bmc.2007.09.008

Reference yield:

: 83647-26-1
1-[4-(2-Dimethylamino-ethoxy)-phenyl]-2-phenyl-1-[3-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-ol

: 82413-20-5
Droloxifene

: 83647-29-4
1-(4-[2-dimethylaminoethoxy]phenyl)-1-(3-hydroxyphenyl)-2-phenylbut-1-ene

Guidance literature:: With hydrogenchloride; In methanol; at 60 - 70 ℃; for 0.5h; Yield given. Yields of byproduct given;
DOI:10.1021/jm00148a020