Technology Process of 5-(3-(4-chloropyrimidin-2-yl)-1-tosyl-1H-indol-5-yl)-N-isopropyl-1,3,4-oxadiazol-2-amine
There total 11 articles about 5-(3-(4-chloropyrimidin-2-yl)-1-tosyl-1H-indol-5-yl)-N-isopropyl-1,3,4-oxadiazol-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(l) iodide;
tetrakis(triphenylphosphine) palladium(0);
In
N,N-dimethyl-formamide;
at 100 ℃;
for 1h;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C
1.2: pH 4
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C
2.2: 0 - 10 °C
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C
3.2: 1.5 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 - 65 °C
5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / 20 °C
6.1: copper(l) iodide / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 1 h / 100 °C / Microwave irradiation
With
copper(l) iodide; iodine; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrazine / ethanol / 12 h / Reflux
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
3.1: diphenylether; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 20 °C
3.2: 18 h / 20 °C
4.1: potassium hydroxide / N,N-dimethyl-formamide; water / 0.08 h / 0 °C
4.2: 1 h
5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 10 °C
5.2: 1 h / 10 °C
6.1: copper(l) iodide / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 1 h / 100 °C / Microwave irradiation
With
copper(l) iodide; diphenylether; sodium hydride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; hydrazine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
