N-{4-[3-(2-chlorophenyl)-4-(1H-1,2,4-triazol-3-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-2-methylpropanamide

Base Information

Chemical Name:N-{4-[3-(2-chlorophenyl)-4-(1H-1,2,4-triazol-3-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-2-methylpropanamide
CAS No.:1445888-57-2
Molecular Formula:C₂₂H₂₁ClN₆O
Molecular Weight:420.901
Hs Code.:

Synonyms:N-{4-[3-(2-chlorophenyl)-4-(1H-1,2,4-triazol-3-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-2-methylpropanamide

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Chemical Property of N-{4-[3-(2-chlorophenyl)-4-(1H-1,2,4-triazol-3-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-2-methylpropanamide

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Technology Process of N-{4-[3-(2-chlorophenyl)-4-(1H-1,2,4-triazol-3-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-2-methylpropanamide

There total 13 articles about N-{4-[3-(2-chlorophenyl)-4-(1H-1,2,4-triazol-3-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1445888-71-0
4-(2-chlorophenyl)-1-[2-(isobutyrylamino)-5-methylpyridin-4-yl]-1H-pyrrole-3-carboxamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1445888-57-2
N-{4-[3-(2-chlorophenyl)-4-(1H-1,2,4-triazol-3-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-2-methylpropanamide

Guidance literature:: 4-(2-chlorophenyl)-1-[2-(isobutyrylamino)-5-methylpyridin-4-yl]-1H-pyrrole-3-carboxamide; N,N-dimethyl-formamide dimethyl acetal; With hydrazine hydrate; In toluene; at 50 ℃; for 2h;

With hydrazine hydrate; In acetic acid; at 20 ℃; for 1h;

Reference yield:

: 1188163-01-0
ethyl 4-(2-chlorophenyl)-1H-pyrrole-3-carboxylate

: 1445888-57-2
N-{4-[3-(2-chlorophenyl)-4-(1H-1,2,4-triazol-3-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-2-methylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate / 1,4-dioxane / 48 h / 105 °C / Sealed tube

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 96 h / 50 °C

3.1: ammonia; HATU; N-ethyl-N,N-diisopropylamine / dichloromethane; 1,4-dioxane / 3 h / 20 °C

4.1: sodium hydroxide; N-ethyl-N,N-diisopropylamine / dichloromethane; methanol / 1 h / 0 °C

5.1: hydrazine hydrate / toluene / 2 h / 50 °C

5.2: 1 h / 20 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; ammonia; water; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;

Reference yield:

: 24393-51-9
(E)-ethyl 2-chlorocinnamate

: 1445888-57-2
N-{4-[3-(2-chlorophenyl)-4-(1H-1,2,4-triazol-3-yl)-1H-pyrrol-1-yl]-5-methylpyridin-2-yl}-2-methylpropanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium t-butanolate / tetrahydrofuran / 3.33 h / -40 - 20 °C

2.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate / 1,4-dioxane / 48 h / 105 °C / Sealed tube

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 96 h / 50 °C

4.1: ammonia; HATU; N-ethyl-N,N-diisopropylamine / dichloromethane; 1,4-dioxane / 3 h / 20 °C

5.1: sodium hydroxide; N-ethyl-N,N-diisopropylamine / dichloromethane; methanol / 1 h / 0 °C

6.1: hydrazine hydrate / toluene / 2 h / 50 °C

6.2: 1 h / 20 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; ammonia; water; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;