5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-Ν-(2.4-difluorophenyl)-2-methoxypyridine-3-sulfonamide

Base Information

Chemical Name:5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-Ν-(2.4-difluorophenyl)-2-methoxypyridine-3-sulfonamide
CAS No.:1383988-97-3
Molecular Formula:C₂₆H₁₉F₂N₅O₄S
Molecular Weight:535.531
Hs Code.:

Synonyms:5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-Ν-(2.4-difluorophenyl)-2-methoxypyridine-3-sulfonamide

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Chemical Property of 5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-Ν-(2.4-difluorophenyl)-2-methoxypyridine-3-sulfonamide

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Technology Process of 5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-Ν-(2.4-difluorophenyl)-2-methoxypyridine-3-sulfonamide

There total 10 articles about 5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-Ν-(2.4-difluorophenyl)-2-methoxypyridine-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 223704-97-0
2-amino-6-iodo-3-phenylquinazolin-4(3H)-one

: 1383992-65-1
N-(2,4-difluorophenyl)-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide

: 1383988-97-3
5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-Ν-(2.4-difluorophenyl)-2-methoxypyridine-3-sulfonamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; at 80 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm400781h

Reference yield: 75.0%

: 1383988-97-3
5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-Ν-(2.4-difluorophenyl)-2-methoxypyridine-3-sulfonamide

Guidance literature:

Reference yield:

: 1383992-41-3
6-iodo-2-((4-methoxybenzyl)amino)-3-phenylquinazolin-4(3H)-one

: 1383988-97-3
5-(2-amino-4-oxo-3-phenyl-3,4-dihydroquinazolin-6-yl)-Ν-(2.4-difluorophenyl)-2-methoxypyridine-3-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 48 h / Reflux

2: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; trifluoroacetic acid; In 1,4-dioxane;
DOI:10.1021/jm400781h