benzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine

Base Information

Chemical Name:benzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine
CAS No.:1401027-56-2
Molecular Formula:C₂₄H₃₀FNO
Molecular Weight:367.507
Hs Code.:

Synonyms:benzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine

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Chemical Property of benzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine

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Technology Process of benzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine

There total 7 articles about benzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethan-1-amine

: 100-52-7
benzaldehyde

: 1401027-56-2
benzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine

Guidance literature:: 2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethan-1-amine; benzaldehyde; With sodium sulfate; In dichloromethane;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h;

Reference yield:

: 855398-57-1
6-oxa-spiro[4.5]decan-9-one

: 1401027-56-2
benzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; ammonium acetate / benzene / 2 h / Dean-Stark; Reflux

2.1: copper(l) iodide / diethyl ether / 1.5 h / 20 °C / Cooling with ice

3.1: potassium hydroxide / ethylene glycol / 3 h / 120 °C

4.1: AD-3 column / methanol / Supercritical conditions; Resolution of racemate

5.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 20 °C

6.1: sodium sulfate / dichloromethane

6.2: 1 h / 0 °C

With copper(l) iodide; lithium aluminium tetrahydride; ammonium acetate; acetic acid; sodium sulfate; potassium hydroxide; In methanol; diethyl ether; dichloromethane; ethylene glycol; benzene;

Reference yield:

: 1401031-14-8
methyl 2-cyano-2-[(9Z)-6-oxaspiro[4.5]decan-9-ylidene]acetate

: 1401027-56-2
benzyl({2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(l) iodide / diethyl ether / 1.5 h / 20 °C / Cooling with ice

2.1: potassium hydroxide / ethylene glycol / 3 h / 120 °C

3.1: AD-3 column / methanol / Supercritical conditions; Resolution of racemate

4.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 20 °C

5.1: sodium sulfate / dichloromethane

5.2: 1 h / 0 °C

With copper(l) iodide; lithium aluminium tetrahydride; sodium sulfate; potassium hydroxide; In methanol; diethyl ether; dichloromethane; ethylene glycol;