C₄₈H₄₃BrN₆O₉

Base Information

Chemical Name:C₄₈H₄₃BrN₆O₉
CAS No.:496789-58-3
Molecular Formula:C₄₈H₄₃BrN₆O₉
Molecular Weight:927.808
Hs Code.:

C<sub>48</sub>H<sub>43</sub>BrN<sub>6</sub>O<sub>9</sub>

Synonyms:C₄₈H₄₃BrN₆O₉

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Chemical Property of C₄₈H₄₃BrN₆O₉

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Technology Process of C₄₈H₄₃BrN₆O₉

There total 20 articles about C₄₈H₄₃BrN₆O₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 496789-49-2
C₄₈H₄₅BrN₆O₁₀

: 496789-58-3
C₄₈H₄₃BrN₆O₉

Guidance literature:: With pyridine; trichlorophosphate; at 25 ℃; for 2h;
DOI:10.1021/ja040092i

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 496789-58-3
C₄₈H₄₃BrN₆O₉

Guidance literature:: Multi-step reaction with 18 steps

1.1: 92 percent / EDC*H₂O; HOBt*H₂O; Et₃N / CH₂Cl₂ / 12 h / 25 °C

2.1: 80 percent / Burgess reagent / tetrahydrofuran / 4 h / Heating

3.1: 90 percent / DBU; BrCCl₃ / CH₂Cl₂ / 3 h / 25 °C

4.1: 83 percent / LiBH₄ / ethanol; tetrahydrofuran / 0 - 25 °C

5.1: NaHMDS / tetrahydrofuran / -78 °C

5.2: 72 percent / n-tetrabutylammonium iodide / tetrahydrofuran / 36 h / 25 °C

6.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

6.2: 73 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C

7.1: 47 percent / p-toluenesulfonic acid monohydrate / 1,2-dichloro-ethane / 0.42 h / Heating

8.1: 4.6 g / aq. NaHCO₃ / dioxane / 2 h / 25 °C

9.1: 85 percent / K₂CO₃ / acetone / 0 - 25 °C

10.1: aq. LiOH / tetrahydrofuran; methanol / 0.33 h / Heating

11.1: trifluoroacetic acid / 0.17 h

12.1: 0.220 g / HATU; 2,4,6-collidine / CH₂Cl₂; dimethylformamide / 12 h / 25 °C

13.1: 65 percent / BCl₃ / CH₂Cl₂ / 2 h / -78 °C

14.1: 70 percent / Et₃N; 4-dimethylaminopyridine / dioxane / 1 h / 25 °C

15.1: 1-hydroxy-1,2-benziodoxol-3(1H)-one / dimethylsulfoxide / 2 h / 25 °C

16.1: 0.072 g / NaClO₂; resorcinol; aq. NaH₂PO₄ / dimethylsulfoxide / 2 h / 25 °C

17.1: 76 percent / EDC*H₂O; HOBT*H₂O; NaHCO₃ / dimethylformamide / 12 h / 25 °C

18.1: 52 percent / POCl₃; pyridine / 2 h / 25 °C

With pyridine; 2,4,6-trimethyl-pyridine; dmap; lithium hydroxide; sodium chlorite; sodium dihydrogenphosphate; lithium borohydride; n-butyllithium; 1-hydroxy-1,2-benzodioxol-3-(1H)-one; Burgess Reagent; Bromotrichloromethane; sodium hexamethyldisilazane; boron trichloride; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; recorcinol; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; 18.1: Robinson-Gabriel cyclodehydration;
DOI:10.1021/ja040092i

Reference yield:

: 158068-97-4
2-<(S)-1--2-methylpropyl>-4-carbomethoxyoxazole

: 496789-58-3
C₄₈H₄₃BrN₆O₉

Guidance literature:: Multi-step reaction with 15 steps

1.1: 83 percent / LiBH₄ / ethanol; tetrahydrofuran / 0 - 25 °C

2.1: NaHMDS / tetrahydrofuran / -78 °C

2.2: 72 percent / n-tetrabutylammonium iodide / tetrahydrofuran / 36 h / 25 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 73 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C

4.1: 47 percent / p-toluenesulfonic acid monohydrate / 1,2-dichloro-ethane / 0.42 h / Heating

5.1: 4.6 g / aq. NaHCO₃ / dioxane / 2 h / 25 °C

6.1: 85 percent / K₂CO₃ / acetone / 0 - 25 °C

7.1: aq. LiOH / tetrahydrofuran; methanol / 0.33 h / Heating

8.1: trifluoroacetic acid / 0.17 h

9.1: 0.220 g / HATU; 2,4,6-collidine / CH₂Cl₂; dimethylformamide / 12 h / 25 °C

10.1: 65 percent / BCl₃ / CH₂Cl₂ / 2 h / -78 °C

11.1: 70 percent / Et₃N; 4-dimethylaminopyridine / dioxane / 1 h / 25 °C

12.1: 1-hydroxy-1,2-benziodoxol-3(1H)-one / dimethylsulfoxide / 2 h / 25 °C

13.1: 0.072 g / NaClO₂; resorcinol; aq. NaH₂PO₄ / dimethylsulfoxide / 2 h / 25 °C

14.1: 76 percent / EDC*H₂O; HOBT*H₂O; NaHCO₃ / dimethylformamide / 12 h / 25 °C

15.1: 52 percent / POCl₃; pyridine / 2 h / 25 °C

With pyridine; 2,4,6-trimethyl-pyridine; dmap; lithium hydroxide; sodium chlorite; sodium dihydrogenphosphate; lithium borohydride; n-butyllithium; 1-hydroxy-1,2-benzodioxol-3-(1H)-one; sodium hexamethyldisilazane; boron trichloride; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; recorcinol; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; 15.1: Robinson-Gabriel cyclodehydration;
DOI:10.1021/ja040092i