N-(2-(4-tert-butoxycarbonyl-piperazin-1-yl)-5-bromophenyl)-2-imino-2H-chromene-3-carboxamide

Base Information

• Chemical Name: N-(2-(4-tert-butoxycarbonyl-piperazin-1-yl)-5-bromophenyl)-2-imino-2H-chromene-3-carboxamide
• CAS No.: 1429200-04-3
• Molecular Formula: C₂₅H₂₇BrN₄O₄
• Molecular Weight: 527.418
• Mol file: 1429200-04-3.mol

Synonyms:N-(2-(4-tert-butoxycarbonyl-piperazin-1-yl)-5-bromophenyl)-2-imino-2H-chromene-3-carboxamide

Chemical Property of N-(2-(4-tert-butoxycarbonyl-piperazin-1-yl)-5-bromophenyl)-2-imino-2H-chromene-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(4-tert-butoxycarbonyl-piperazin-1-yl)-5-bromophenyl)-2-imino-2H-chromene-3-carboxamide

There total 5 articles about N-(2-(4-tert-butoxycarbonyl-piperazin-1-yl)-5-bromophenyl)-2-imino-2H-chromene-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-(2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-bromophenyl)-2-cyanoacetamide (1429200-01-0) + salicylaldehyde (90-02-8) → N-(2-(4-tert-butoxycarbonyl-piperazin-1-yl)-5-bromophenyl)-2-imino-2H-chromene-3-carboxamide (1429200-04-3)

Guidance literature:

With piperidine; In methanol; at 50 ℃; for 7h;

DOI:10.1016/j.bmc.2013.01.064

Reference yield:

1,4-dibromo-2-nitrobenzene (3460-18-2) → N-(2-(4-tert-butoxycarbonyl-piperazin-1-yl)-5-bromophenyl)-2-imino-2H-chromene-3-carboxamide (1429200-04-3)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / isopropyl alcohol / 20 h / 70 °C

2: sodium carbonate; sodium dithionate / methanol; water / 70 °C

3: toluene / 20 °C / Reflux

4: piperidine / methanol / 7 h / 50 °C

With piperidine; sodium dithionate; sodium carbonate; triethylamine; In methanol; water; isopropyl alcohol; toluene;

DOI:10.1016/j.bmc.2013.01.064

Reference yield:

1-t-Butoxycarbonylpiperazine (57260-71-6) → N-(2-(4-tert-butoxycarbonyl-piperazin-1-yl)-5-bromophenyl)-2-imino-2H-chromene-3-carboxamide (1429200-04-3)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / isopropyl alcohol / 20 h / 70 °C

2: sodium carbonate; sodium dithionate / methanol; water / 70 °C

3: toluene / 20 °C / Reflux

4: piperidine / methanol / 7 h / 50 °C

With piperidine; sodium dithionate; sodium carbonate; triethylamine; In methanol; water; isopropyl alcohol; toluene;

DOI:10.1016/j.bmc.2013.01.064

upstream raw materials:

N-(2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-bromophenyl)-2-cyanoacetamide

salicylaldehyde

1,4-dibromo-2-nitrobenzene

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

N-(5-bromo-2-(piperazin-1-yl)phenyl)-2-(phenylimino)-2H-chromene-3-carboxamide

N-(5-bromo-2-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)-2-(phenylimino)-2H-chromene-3-carboxamide

N-(5-bromo-2-(4-(3-cyanopropyl)piperazin-1-yl)phenyl)-2-(phenylimino)-2H-chromene-3-carboxamide

N-(2-(4-(3-cyanobenzyl)piperazin-1-yl)-5-bromophenyl)-2-(phenylimino)-2H-chromene-3-carboxamide