4'-<(4,5-dihydro-4-oxo-2-propyl-3H-imidazo<4,5-c>pyridin-3-yl)methyl>bipheny-2-carbonitrile

Base Information

• Chemical Name: 4'-<(4,5-dihydro-4-oxo-2-propyl-3H-imidazo<4,5-c>pyridin-3-yl)methyl>bipheny-2-carbonitrile
• CAS No.: 156221-78-2
• Molecular Formula: C₂₃H₂₀N₄O
• Molecular Weight: 368.438
• Mol file: 156221-78-2.mol

Synonyms:4'-<(4,5-dihydro-4-oxo-2-propyl-3H-imidazo<4,5-c>pyridin-3-yl)methyl>bipheny-2-carbonitrile

Chemical Property of 4'-<(4,5-dihydro-4-oxo-2-propyl-3H-imidazo<4,5-c>pyridin-3-yl)methyl>bipheny-2-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-<(4,5-dihydro-4-oxo-2-propyl-3H-imidazo<4,5-c>pyridin-3-yl)methyl>bipheny-2-carbonitrile

There total 3 articles about 4'-<(4,5-dihydro-4-oxo-2-propyl-3H-imidazo<4,5-c>pyridin-3-yl)methyl>bipheny-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile (114772-54-2) + 4,5-dihydro-4-oxo-2-propyl-3H-imidazo<4,5-c>pyridine (152460-64-5) → 4'-<(4,5-dihydro-4-oxo-2-propyl-3H-imidazo<4,5-c>pyridin-3-yl)methyl>bipheny-2-carbonitrile (156221-78-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jm00037a014

Reference yield:

2-chloropyridine-3,4-diamine (39217-08-8) → 4'-<(4,5-dihydro-4-oxo-2-propyl-3H-imidazo<4,5-c>pyridin-3-yl)methyl>bipheny-2-carbonitrile (156221-78-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 61 percent / polyphosphoric acid / 80 °C

2: 52 percent / 15percent hydrochloric acid / dimethylformamide / Heating

3: 43 percent / potassium carbonate / dimethylformamide / Ambient temperature

With hydrogenchloride; PPA; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jm00037a014

Reference yield:

4-chloro-2-propyl-3H-imidazo<4,5-c>pyridine (156221-77-1) → 4'-<(4,5-dihydro-4-oxo-2-propyl-3H-imidazo<4,5-c>pyridin-3-yl)methyl>bipheny-2-carbonitrile (156221-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / 15percent hydrochloric acid / dimethylformamide / Heating

2: 43 percent / potassium carbonate / dimethylformamide / Ambient temperature

With hydrogenchloride; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jm00037a014

upstream raw materials:

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

4,5-dihydro-4-oxo-2-propyl-3H-imidazo<4,5-c>pyridine

2-chloropyridine-3,4-diamine

4-chloro-2-propyl-3H-imidazo<4,5-c>pyridine

Downstream raw materials:

4'-<<4,5-dihydro-5-<(N,N-dimethylcarbamoyl)methyl>-4-oxo-2-propyl-3H-imidazo<4,5-c>pyridin-3-yl>methyl>biphenyl-2-carbonitrile