5,6-dimethoxy-2,3-dihydro-1H-inden-2-amine

Base Information

• Chemical Name: 5,6-dimethoxy-2,3-dihydro-1H-inden-2-amine
• CAS No.: 83598-55-4
• Molecular Formula: C11H15 N O2
• Molecular Weight: 193.246
• Hs Code.: 2922199090
• DSSTox Substance ID: DTXSID50452994
• Nikkaji Number: J1.681.418K
• Wikidata: Q82273946
• ChEMBL ID: CHEMBL142452
• Mol file: 83598-55-4.mol

Synonyms:5,6-dimethoxy-2,3-dihydro-1H-inden-2-amine;83598-55-4;1H-Inden-2-amine, 2,3-dihydro-5,6-dimethoxy-;5,6-dimethoxy-2-aminoindan;5,6-Dimethoxyindan-2-amine;5.6-dimethoxy-2-indanylamine;5,6-Dimethoxy-2-indanylamine;CHEMBL142452;SCHEMBL3041826;DTXSID50452994;TZASGTHDRXFGHT-UHFFFAOYSA-N;MFCD08234972;AKOS015894553;FF-0041;MB05912;FT-0683875;A937556;J-516539

Chemical Property of 5,6-dimethoxy-2,3-dihydro-1H-inden-2-amine

Chemical Property:

• PSA: 44.48000
• LogP: 1.83000
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 193.110278721
• Heavy Atom Count: 14
• Complexity: 178

Purity/Quality:

98%min ^*data from raw suppliers

5,6-Dimethoxy-2,3-dihydro-1H-inden-2-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C2CC(CC2=C1)N)OC

Technology Process of 5,6-dimethoxy-2,3-dihydro-1H-inden-2-amine

There total 7 articles about 5,6-dimethoxy-2,3-dihydro-1H-inden-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

5,6-dimethoxy-indan-1,2-dione-2-oxime (2107-85-9) → 5,6-Dimethoxy-2-indanylamine (83598-55-4)

Guidance literature:

With sulfuric acid; palladium 10% on activated carbon; hydrogen; acetic acid; at 19 - 22 ℃; for 48h; under 300.03 - 3000.3 Torr; Inert atmosphere;

DOI:10.1021/jm100068m

Reference yield:

5,6-dimethoxy-1H-inden-1,2(3H)-dione 2-oxime → 5,6-Dimethoxy-2-indanylamine (83598-55-4)

Guidance literature:

With sodium hydroxide; sulfuric acid; palladium-carbon; In water; acetic acid;

Reference yield:

5,6-dimethoxy-1-indanone (2107-69-9) → 5,6-Dimethoxy-2-indanylamine (83598-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / n-butylnitrite; conc. aq. HCl / methanol / 0.5 h / 40 °C

2: H₂; H₂SO₄ / 10percent Pd/C / acetic acid / 7 h / 2585.81 Torr

With hydrogenchloride; n-Butyl nitrite; sulfuric acid; hydrogen; 10percent Pd/C; In methanol; acetic acid;

DOI:10.1021/jm010145w

upstream raw materials:

5,6-dimethoxy-indan-1,2-dione-2-oxime

5,6-dimethoxy-1-indanone

3-(3,4-dimethoxy-phenyl)-propionyl chloride

Downstream raw materials:

N-(5,6-dimethoxy-indan-2-yl)-2-phenyl-N-propyl-acetamide

N-(5,6-dimethoxy-indan-2-yl)-3-phenyl-N-propyl-propionamide

[2-(4-bromo-phenyl)-ethyl]-(5,6-dimethoxy-indan-2-yl)-propyl-amine

2-(4-bromo-phenyl)-N-(5,6-dimethoxy-indan-2-yl)-N-propyl-acetamide