(S)-1-{1-[(S)-2-hydroxy-2-(4-nitrophenyl)ethyl]-1H-1,2,3-triazol-4-yl}hexan-1-ol

Base Information

Chemical Name:(S)-1-{1-[(S)-2-hydroxy-2-(4-nitrophenyl)ethyl]-1H-1,2,3-triazol-4-yl}hexan-1-ol
CAS No.:1427301-57-2
Molecular Formula:C₁₆H₂₂N₄O₄
Molecular Weight:334.375
Hs Code.:

Synonyms:(S)-1-{1-[(S)-2-hydroxy-2-(4-nitrophenyl)ethyl]-1H-1,2,3-triazol-4-yl}hexan-1-ol

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Chemical Property of (S)-1-{1-[(S)-2-hydroxy-2-(4-nitrophenyl)ethyl]-1H-1,2,3-triazol-4-yl}hexan-1-ol

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Technology Process of (S)-1-{1-[(S)-2-hydroxy-2-(4-nitrophenyl)ethyl]-1H-1,2,3-triazol-4-yl}hexan-1-ol

There total 3 articles about (S)-1-{1-[(S)-2-hydroxy-2-(4-nitrophenyl)ethyl]-1H-1,2,3-triazol-4-yl}hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 27593-19-7
oct-1-yn-3-one

: 26086-61-3
2-azido-1-(4-nitrophenyl)ethan-1-one

: 1427301-57-2
(S)-1-{1-[(S)-2-hydroxy-2-(4-nitrophenyl)ethyl]-1H-1,2,3-triazol-4-yl}hexan-1-ol

Guidance literature:: oct-1-yn-3-one; 2-azido-1-(4-nitrophenyl)ethan-1-one; With LBADH from Lactobacillus brevis; In aq. phosphate buffer; dimethyl sulfoxide; isopropyl alcohol; at 30 ℃; for 24h; pH=7.5; Enzymatic reaction;

With copper; copper(II) sulfate; In aq. phosphate buffer; water; dimethyl sulfoxide; isopropyl alcohol; at 60 - 80 ℃; for 24h; Reagent/catalyst; stereoselective reaction;
DOI:10.1039/c3cc38674k

Reference yield:

: 99-81-0
4-Nitrophenacyl bromide

: 1427301-57-2
(S)-1-{1-[(S)-2-hydroxy-2-(4-nitrophenyl)ethyl]-1H-1,2,3-triazol-4-yl}hexan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium azide / water; ethanol / 20 °C

2.1: LBADH from Lactobacillus brevis / aq. phosphate buffer; isopropyl alcohol; dimethyl sulfoxide / 24 h / 30 °C / pH 7.5 / Enzymatic reaction

2.2: 24 h / 60 - 80 °C

With sodium azide; LBADH from Lactobacillus brevis; In aq. phosphate buffer; ethanol; water; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1039/c3cc38674k

Reference yield:

: 818-72-4,37911-28-7
1-Octyn-3-ol

: 1427301-57-2
(S)-1-{1-[(S)-2-hydroxy-2-(4-nitrophenyl)ethyl]-1H-1,2,3-triazol-4-yl}hexan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: Jones reagent / acetone / 1 h / 0 - 20 °C

2.1: LBADH from Lactobacillus brevis / aq. phosphate buffer; isopropyl alcohol; dimethyl sulfoxide / 24 h / 30 °C / pH 7.5 / Enzymatic reaction

2.2: 24 h / 60 - 80 °C

With Jones reagent; LBADH from Lactobacillus brevis; In aq. phosphate buffer; dimethyl sulfoxide; isopropyl alcohol; acetone;
DOI:10.1039/c3cc38674k