27593-19-7

Basic information

• Product Name: 1-Octyn-3-one
• CAS NO: 27593-19-7
• Molecular Formula: C8H12O
• Molecular Weight: 124.183
• Mol File: 27593-19-7.mol
• Article Data: 42

Chemical Properties

• CAS DataBase Reference: 1-Octyn-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Octyn-3-one(27593-19-7)
• EPA Substance Registry System: 1-Octyn-3-one(27593-19-7)

Safety Data

• Hazardous Substances Data: 27593-19-7(Hazardous Substances Data)

Usage

General Description

1-Octyn-3-one, also known as oct-1-yn-3-one, is an organic compound classified as an alkyne-ketone. It is a colorless to pale yellow liquid with a sharp and acrid odor, and it is primarily used as an intermediate in the synthesis of various chemical compounds. It is known for its reactivity and is used in the production of pharmaceuticals, pesticides, and other fine chemicals. Due to its unique structure and properties, 1-Octyn-3-one is also utilized in organic chemistry research and experimental studies. Additionally, it is considered to be a potential building block for the development of novel materials and bioactive compounds. However, it is important to handle this chemical with caution as it is flammable and may cause respiratory irritation and skin sensitization.

Upstream product

• 66-25-1 hexanal 
• 629-05-0 n-octyne 
• 17962-52-6 1-(trimethylsilyl)-1,2-octadiene 
• 142-61-0 Hexanoyl chloride 
• 4301-14-8 acetylenemagnesium bromide 
• 818-72-4 1-Octyn-3-ol 

Downstream Products

• 32556-71-1 1-octyn-3-ol 
• 72443-72-2 (R)-1-((R)-6-Benzyloxy-2,5,7,8-tetramethyl-chroman-2-yl)-pent-3-yn-2-ol 
• 136730-69-3 (Z,Z)-bis(3-oxo-1-octenyl)sulfide 
• 126959-20-4 2,4,6-tri(2-oxoheptyl)-1,3,5-trithiane 
• 136730-72-8 (Z,E)-bis(3-oxo-1-octenyl)sulfide 
• 136757-16-9 (E,E)-bis(3-oxo-1-octenyl)sulfide 
• 108161-47-3 (Z)-1-Bromo-oct-1-en-3-one 
• 52418-89-0 (E)-1-bromo-1-octen-3-one 
• 109572-45-4 2-Hydroxy-3-[1-iodo-meth-(Z)-ylidene]-nonan-4-one 
• 109572-47-6 2-Hydroxy-3-[1-iodo-meth-(E)-ylidene]-nonan-4-one 
• 252557-58-7 (E)-1-cyano-2-pentyl-1-buten-3-yne 
• 252557-57-6 (Z)-1-cyano-2-pentyl-1-buten-3-yne 
• 818-72-4 1-Octyn-3-ol 
• 1207737-22-1 C₂₀H₃₇N₃O 

Relevant articles and documents

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Isoketals form cytotoxic phosphatidylethanolamine adducts in cells

Levuglandins and their stereo- and regio-isomers (termed isolevuglandins or isoketals) are γ-ketoaldehydes (IsoK) that rapidly react with lysines to form stable protein adducts. IsoK protein adduct levels increase in several pathological conditions including cardiovascular disease. IsoKs can induce ion channel dysfunction and cell death, potentially by adducting to cellular proteins. However, IsoKs also adduct to phosphatidylethanolamine (PE) in vitro, and whether PE adducts form in cells or contribute to the effects of IsoKs is unknown. When radiolabeled IsoK was added to HEK293 cells, 40% of the radiolabel extracted into the chloroform lower phase suggesting the possible formation of PE adducts. We therefore developed methods to measure IsoK-PE adducts in cells. IsoK-PE was quantified by LC/MS/MS after hydrolysis to IsoK-ethanolamine by Streptomyces chromofuscus phospholipase D. In HEK293 and human umbilical vein endothelial cells (HUVEC), IsoK dose-dependently increased PE adduct concentrations to a greater extent than protein adduct. To test the biological significance of IsoK-PE formation, we treated HUVEC with IsoK-PE. IsoK-PE dose dependently induced cytotoxicity (LC50 2.2 μM). These results indicate that cellular PE is a significant target of IsoKs, and that formation of PE adducts may mediate some of the biological effects of IsoKs relevant to disease. Copyright

Aerobic oxidation of alcohols catalyzed by in situ generated gold nanoparticles inside the channels of periodic mesoporous organosilica with ionic liquid framework

In situ generated gold nanoparticles inside the nanospaces of periodic mesoporous organosilica with an imidazolium framework (Au?PMO-IL) were found to be highly active, selective, and reusable catalysts for the aerobic oxidation of activated and nonactivated alcohols under mild reaction conditions. The catalyst was characterized by nitrogen adsorption-desorption measurement, thermogravimetric analysis (TGA), transmission electron microscopy (TEM), elemental analysis (EA), diffuse reflectance infrared Fourier transform spectroscopy (DRIFT), X-ray photoelectron spectroscopy (XPS), and inductively coupled plasma atomic emission spectroscopy (ICP-AES). The catalyst exhibited excellent catalytic activity in the presence of either Cs2CO3 (35 °C) or K2CO3 (60 °C) as reaction bases in toluene as a reaction solvent. Under both reaction conditions, various types of alcohols (up to 35 examples) including activated benzylic, primary and secondary aliphatic, heterocyclic, and challenging cyclic aliphatic alcohols converted to the expected carbonyl compounds in good to excellent yields and selectivity. The catalyst was also recovered and reused for at least seven reaction cycles. Data from three independent leaching tests indicated that amounts of leached gold particles were negligible (0.2 ppm). It is believed that the combination of bridged imidazolium groups and confined nanospaces of PMO-IL might be a major reason explaining the remarkable stabilization and homogeneous distribution of in situ generated gold nanoparticles, thus resulting in the highly active and recyclable catalyst system.

Styrene as 4π-Component in Zn(II)-Catalyzed Intermolecular Diels-Alder/Ene Tandem Reaction

A mild Zn-catalyzed intermolecular Diels-Alder/ene tandem reaction with styrene as a 4π-component is reported. A variety of dihydronaphthalene products could be prepared in moderate to good yields. Moreover, a combination of DFT calculations and experiments was performed to further understand the mechanism of this unique tandem reaction.