4-((1R,2S,4S,6R)-4-(4-hydroxyphenylethyl)-3,7-dioxabicyclo[4.1.0]heptan-2-yl)phenol

Base Information

Chemical Name:4-((1R,2S,4S,6R)-4-(4-hydroxyphenylethyl)-3,7-dioxabicyclo[4.1.0]heptan-2-yl)phenol
CAS No.:1288996-99-5
Molecular Formula:C₁₉H₂₀O₄
Molecular Weight:312.365
Hs Code.:

Synonyms:4-((1R,2S,4S,6R)-4-(4-hydroxyphenylethyl)-3,7-dioxabicyclo[4.1.0]heptan-2-yl)phenol

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Chemical Property of 4-((1R,2S,4S,6R)-4-(4-hydroxyphenylethyl)-3,7-dioxabicyclo[4.1.0]heptan-2-yl)phenol

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Technology Process of 4-((1R,2S,4S,6R)-4-(4-hydroxyphenylethyl)-3,7-dioxabicyclo[4.1.0]heptan-2-yl)phenol

There total 3 articles about 4-((1R,2S,4S,6R)-4-(4-hydroxyphenylethyl)-3,7-dioxabicyclo[4.1.0]heptan-2-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1288996-98-4
C₂₅H₃₄O₄Si

: 1288996-99-5
4-((1R,2S,4S,6R)-4-(4-hydroxyphenylethyl)-3,7-dioxabicyclo[4.1.0]heptan-2-yl)phenol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jo2002787

Reference yield:

: 1288996-76-8
4-((2S,6R)-6-(4-(tert-butyldimethylsilyloxy)phenylethyl)-5,6-dihydro-2H-pyran-2-yl)phenol

: 1288996-99-5
4-((1R,2S,4S,6R)-4-(4-hydroxyphenylethyl)-3,7-dioxabicyclo[4.1.0]heptan-2-yl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo2002787

Reference yield:

: 1202784-98-2
(R)-2-[4-(tert-butyldimethylsilyloxy)phenethyl]-3,4-dihydro-2H-pyran

: 1288996-99-5
4-((1R,2S,4S,6R)-4-(4-hydroxyphenylethyl)-3,7-dioxabicyclo[4.1.0]heptan-2-yl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate; palladium diacetate / acetonitrile / 3 h / 20 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; sodium acetate; palladium diacetate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; acetonitrile; 1: Mizoroki-Heck reaction;
DOI:10.1021/jo2002787