(1S,2S,3S)-2-(4-fluorophenyl)-3-fluoro-N-methoxy-N-methyl-cyclopropanecarboxamide

Base Information

Chemical Name:(1S,2S,3S)-2-(4-fluorophenyl)-3-fluoro-N-methoxy-N-methyl-cyclopropanecarboxamide
CAS No.:1422176-90-6
Molecular Formula:C₁₂H₁₃F₂NO₂
Molecular Weight:241.238
Hs Code.:

Synonyms:(1S,2S,3S)-2-(4-fluorophenyl)-3-fluoro-N-methoxy-N-methyl-cyclopropanecarboxamide

Suppliers and Price of (1S,2S,3S)-2-(4-fluorophenyl)-3-fluoro-N-methoxy-N-methyl-cyclopropanecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S,3S)-2-(4-fluorophenyl)-3-fluoro-N-methoxy-N-methyl-cyclopropanecarboxamide

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Technology Process of (1S,2S,3S)-2-(4-fluorophenyl)-3-fluoro-N-methoxy-N-methyl-cyclopropanecarboxamide

There total 3 articles about (1S,2S,3S)-2-(4-fluorophenyl)-3-fluoro-N-methoxy-N-methyl-cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1355061-76-5
C₁₁H₁₂FNO₂

: 1422176-84-8
(R)-N-tosyl-S-fluoromethyl-S-phenylsulfoximine

: 1422176-90-6
(1S,2S,3S)-2-(4-fluorophenyl)-3-fluoro-N-methoxy-N-methyl-cyclopropanecarboxamide

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 3.33333h; optical yield given as %ee; stereoselective reaction; Inert atmosphere;
DOI:10.1002/anie.201202451

Reference yield: 88.0%

: 1355061-76-5
C₁₁H₁₂FNO₂

: 1422176-84-8
(R)-N-tosyl-S-fluoromethyl-S-phenylsulfoximine

: 1422176-90-6
(1S,2S,3S)-2-(4-fluorophenyl)-3-fluoro-N-methoxy-N-methyl-cyclopropanecarboxamide

: C₁₂H₁₃F₂NO₂

Guidance literature:: With lithium hexamethyldisilazane; In toluene; at -78 - 20 ℃; for 3.33333h; optical yield given as %ee; stereoselective reaction; Inert atmosphere;
DOI:10.1002/anie.201202451