4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphtoxy)ethoxy]benzaldehyde

Base Information

Chemical Name:4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphtoxy)ethoxy]benzaldehyde
CAS No.:701294-88-4
Molecular Formula:C₂₃H₂₈O₃
Molecular Weight:352.474
Hs Code.:

Synonyms:4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphtoxy)ethoxy]benzaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphtoxy)ethoxy]benzaldehyde

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Technology Process of 4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphtoxy)ethoxy]benzaldehyde

There total 1 articles about 4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphtoxy)ethoxy]benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.4%

: 22824-31-3
5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ol

: 52191-15-8
4-(2-bromoethyloxy)benzaldehyde

: 701294-88-4
4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphtoxy)ethoxy]benzaldehyde

Guidance literature:: With potassium hydroxide; In ethanol; for 8h; Heating / reflux;

Reference yield: 98.0%

: 108-59-8
malonic acid dimethyl ester

: 701294-88-4
4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphtoxy)ethoxy]benzaldehyde

: 701294-89-5
dimethyl 4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphtoxy)ethoxy]benzylidenemalonate

Guidance literature:: piperdinium acetate; In toluene; for 8h; Heating / reflux;

Reference yield:

: 701294-88-4
4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphtoxy)ethoxy]benzaldehyde

: 2-[4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphtoxy)ethoxy]benzyl] malonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: piperidinium acetate / toluene / Heating

2: H₂ / Pd/C / 20 °C

3: aq. NaOH / 20 °C

With sodium hydroxide; hydrogen; piperdinium acetate; palladium on activated charcoal; In toluene; 1: Knoevenagel condensation;
DOI:10.1016/j.bmcl.2004.04.053