2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylic acid

Base Information

Chemical Name:2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylic acid
CAS No.:1235450-96-0
Molecular Formula:C₂₄H₂₅N₇O₃S
Molecular Weight:491.574
Hs Code.:

Synonyms:2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylic acid

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Chemical Property of 2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylic acid

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Technology Process of 2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylic acid

There total 14 articles about 2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1235450-95-9
ethyl 2-(((2-(4-(acetamidomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidine-6-yl)Methyl)(methyl)amino)pyrimidine-5-carboxylate

: 1235450-96-0
2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylic acid

Guidance literature:: ethyl 2-(((2-(4-(acetamidomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidine-6-yl)Methyl)(methyl)amino)pyrimidine-5-carboxylate; With hydrogenchloride; water; In tetrahydrofuran; at 85 ℃; for 12h;

With sodium hydroxide; In tetrahydrofuran; water; at 0 ℃; pH=4;

Reference yield:

: 89793-12-4
ethyl 2-chloropyrimidine-5-carboxylate

: 1235450-96-0
2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

2.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 2 h / 130 °C / Inert atmosphere; Microwave irradiation

3.1: hydrogenchloride; water / tetrahydrofuran / 12 h / 85 °C

3.2: 0 °C / pH 4

With hydrogenchloride; water; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; water; toluene; acetonitrile;

Reference yield:

: 16233-51-5
1H-thieno[3,2-d]pyrimidine-2,4-dione

: 1235450-96-0
2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: trichlorophosphate / 10 h / Reflux

2.1: methanol / 1 h / 20 °C

3.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1 h / -78 °C

3.2: 11 h / -78 - 20 °C

4.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

5.1: triphenylphosphine; N-Bromosuccinimide / dichloromethane / 3 h / 25 °C

6.1: ethanol / 1 h / Reflux

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

8.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 2 h / 130 °C / Inert atmosphere; Microwave irradiation

9.1: hydrogenchloride; water / tetrahydrofuran / 12 h / 85 °C

9.2: 0 °C / pH 4

With hydrogenchloride; methanol; sodium tetrahydroborate; N-Bromosuccinimide; water; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium diisopropyl amide; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; toluene; acetonitrile;