methyl 2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate

Base Information

Chemical Name:methyl 2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate
CAS No.:1235450-94-8
Molecular Formula:C₂₅H₂₇N₇O₃S
Molecular Weight:505.6
Hs Code.:

Synonyms:methyl 2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate

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Chemical Property of methyl 2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate

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Technology Process of methyl 2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate

There total 15 articles about methyl 2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 67-56-1
methanol

: 1235450-96-0
2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylic acid

: 1235450-94-8
methyl 2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate

Guidance literature:: methanol; 2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylic acid; With thionyl chloride; at 0 ℃; for 1.5h; Reflux;

With sodium hydrogencarbonate; In water; pH=8;

Reference yield:

: 89793-12-4
ethyl 2-chloropyrimidine-5-carboxylate

: 1235450-94-8
methyl 2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

2.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 2 h / 130 °C / Inert atmosphere; Microwave irradiation

3.1: hydrogenchloride; water / tetrahydrofuran / 12 h / 85 °C

3.2: 0 °C / pH 4

4.1: thionyl chloride / 1.5 h / 0 °C / Reflux

4.2: pH 8

With hydrogenchloride; thionyl chloride; water; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; water; toluene; acetonitrile;

Reference yield:

: 16233-51-5
1H-thieno[3,2-d]pyrimidine-2,4-dione

: 1235450-94-8
methyl 2-(((2-(4-(aminomethyl)phenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: trichlorophosphate / 10 h / Reflux

2.1: methanol / 1 h / 20 °C

3.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1 h / -78 °C

3.2: 11 h / -78 - 20 °C

4.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

5.1: triphenylphosphine; N-Bromosuccinimide / dichloromethane / 3 h / 25 °C

6.1: ethanol / 1 h / Reflux

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

8.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 2 h / 130 °C / Inert atmosphere; Microwave irradiation

9.1: hydrogenchloride; water / tetrahydrofuran / 12 h / 85 °C

9.2: 0 °C / pH 4

10.1: thionyl chloride / 1.5 h / 0 °C / Reflux

10.2: pH 8

With hydrogenchloride; methanol; sodium tetrahydroborate; N-Bromosuccinimide; thionyl chloride; water; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium diisopropyl amide; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; toluene; acetonitrile;