2-[(dimethylamino)methyleneimino]-4-benzyloxy-5-N-benzyloxymethyl-pyrrolo[3,2-d]pyrimidine

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Chemical Name:2-[(dimethylamino)methyleneimino]-4-benzyloxy-5-N-benzyloxymethyl-pyrrolo[3,2-d]pyrimidine
CAS No.:1446175-18-3
Molecular Formula:C₂₄H₂₅N₅O₂
Molecular Weight:415.495
Hs Code.:

Synonyms:2-[(dimethylamino)methyleneimino]-4-benzyloxy-5-N-benzyloxymethyl-pyrrolo[3,2-d]pyrimidine

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Chemical Property of 2-[(dimethylamino)methyleneimino]-4-benzyloxy-5-N-benzyloxymethyl-pyrrolo[3,2-d]pyrimidine

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Technology Process of 2-[(dimethylamino)methyleneimino]-4-benzyloxy-5-N-benzyloxymethyl-pyrrolo[3,2-d]pyrimidine

There total 1 articles about 2-[(dimethylamino)methyleneimino]-4-benzyloxy-5-N-benzyloxymethyl-pyrrolo[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 3587-60-8
Benzyloxymethyl chloride

: 1446175-19-4
C₁₆H₁₇N₅O

: 1446175-18-3
2-[(dimethylamino)methyleneimino]-4-benzyloxy-5-N-benzyloxymethyl-pyrrolo[3,2-d]pyrimidine

Guidance literature:: C₁₆H₁₇N₅O; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h; Inert atmosphere;

Benzyloxymethyl chloride; In tetrahydrofuran; mineral oil; for 1h; Inert atmosphere;
DOI:10.1021/jo400913k

Reference yield: 64.0%

: 1446175-18-3
2-[(dimethylamino)methyleneimino]-4-benzyloxy-5-N-benzyloxymethyl-pyrrolo[3,2-d]pyrimidine

: 1446175-20-7
7-iodo-2-[(dimethylamino)methyleneimino]-4-benzyloxy-5-benzyloxymethyl-pyrrolo[3,2-d]pyrimidine

Guidance literature:: With N-iodo-succinimide; In dichloromethane; Inert atmosphere;
DOI:10.1021/jo400913k

Reference yield:

: 1446175-18-3
2-[(dimethylamino)methyleneimino]-4-benzyloxy-5-N-benzyloxymethyl-pyrrolo[3,2-d]pyrimidine

: C₄₆H₅₀N₄O₅Si

Guidance literature:: Multi-step reaction with 2 steps

1: N-iodo-succinimide / dichloromethane / Inert atmosphere

2: tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 48 h / 40 °C

With N-iodo-succinimide; tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide; 2: |Heck Reaction;
DOI:10.1021/jo400913k