8b,8c-di(4-methylphenyl)perhydro-2,6-dioxa-3a,4a,7a,8a-tetraazacyclopenta[def]fluorene-4,8-dione

Base Information

• Chemical Name: 8b,8c-di(4-methylphenyl)perhydro-2,6-dioxa-3a,4a,7a,8a-tetraazacyclopenta[def]fluorene-4,8-dione
• CAS No.: 176243-64-4
• Molecular Formula: C₂₂H₂₂N₄O₄
• Molecular Weight: 406.441
• Mol file: 176243-64-4.mol

Synonyms:8b,8c-di(4-methylphenyl)perhydro-2,6-dioxa-3a,4a,7a,8a-tetraazacyclopenta[def]fluorene-4,8-dione

Chemical Property of 8b,8c-di(4-methylphenyl)perhydro-2,6-dioxa-3a,4a,7a,8a-tetraazacyclopenta[def]fluorene-4,8-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8b,8c-di(4-methylphenyl)perhydro-2,6-dioxa-3a,4a,7a,8a-tetraazacyclopenta[def]fluorene-4,8-dione

There total 1 articles about 8b,8c-di(4-methylphenyl)perhydro-2,6-dioxa-3a,4a,7a,8a-tetraazacyclopenta[def]fluorene-4,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3a,6a-di-p-tolyl-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione → 8b,8c-di(4-methylphenyl)perhydro-2,6-dioxa-3a,4a,7a,8a-tetraazacyclopenta[def]fluorene-4,8-dione (176243-64-4)

Guidance literature:

formaldehyd; 3a,6a-di-p-tolyl-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione; With sodium hydroxide; In dimethyl sulfoxide; for 16h;

With hydrogenchloride; In dimethyl sulfoxide; for 2h; Heating;

DOI:10.1021/jo035130f

Reference yield: 96.0%

8b,8c-di(4-methylphenyl)perhydro-2,6-dioxa-3a,4a,7a,8a-tetraazacyclopenta[def]fluorene-4,8-dione (176243-64-4) → 4-[8b-(4-carboxyphenyl)-4,8-dioxoperhydro-2,6-dioxa-3a,4a,7a,8a-tetraazacyclopenta[dcf]fluoren-8-yl]-benzoic acid (635320-36-4)

Guidance literature:

With potassium permanganate; for 16h; Heating;

DOI:10.1021/jo035130f

Reference yield:

8b,8c-di(4-methylphenyl)perhydro-2,6-dioxa-3a,4a,7a,8a-tetraazacyclopenta[def]fluorene-4,8-dione (176243-64-4) → 4-[13b-(4-carboxyphenyl)-1,4,8,11-tetramethoxy-6,13-dioxo-5,7,12,13b,13c,14-hexahydro-5a,6a,12a,13a-tetraazabenzo[5,6]azuleno[2,1,8-ija]benzo[f]azulen-13-yl]benzoic acid (325463-28-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / aq. KMnO₄ / 16 h / Heating

2: 56 percent / H₂SO₄ / 16 h / Heating

3: 81 percent / CF₃CO₂H; Ac₂O / 64 h / 100 °C

4: 97 percent / aq. NaOH / dioxane; methanol / 16 h

With sodium hydroxide; potassium permanganate; sulfuric acid; acetic anhydride; trifluoroacetic acid; In 1,4-dioxane; methanol;

DOI:10.1021/jo035130f

upstream raw materials:

formaldehyd

Downstream raw materials:

4-[8b-(4-carboxyphenyl)-4,8-dioxoperhydro-2,6-dioxa-3a,4a,7a,8a-tetraazacyclopenta[dcf]fluoren-8-yl]-benzoic acid

methyl 4-[1,4,8,11-tetramethoxy-13b-[4-(methoxycarbonyl)phenyl]-6,13-dioxo-5,7,12,13b,13c,14-hexahydro-5a,6a,12a,13a-tetraazabenzo[5,6]azuleno[2,l,8-ija]benzo[f]azulen-13-yl]benzoate

4-[13b-(4-carboxyphenyl)-1,4,8,11-tetramethoxy-6,13-dioxo-5,7,12,13b,13c,14-hexahydro-5a,6a,12a,13a-tetraazabenzo[5,6]azuleno[2,1,8-ija]benzo[f]azulen-13-yl]benzoic acid

methyl 4-[8b-[4-(methoxycarbonyl)phenyl]-4,8-dioxoperhydro-2,6-dioxa-3a,4a,7a,8a-tetraazacyclopenta[def]fluoren-8-yl]benzoate