N-BOC-TRANS-4-IODO-L-PROLINE METHYL ESTER

Base Information

Chemical Name:N-BOC-TRANS-4-IODO-L-PROLINE METHYL ESTER
CAS No.:83548-47-4
Molecular Formula:C₁₁H₁₈INO₄
Molecular Weight:355.173
Hs Code.:
Mol file:83548-47-4.mol

Synonyms:1,2-Pyrrolidinedicarboxylicacid, 4-iodo-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S-cis)-

Suppliers and Price of N-BOC-TRANS-4-IODO-L-PROLINE METHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
N-BOC-TRANS-4-IODO-L-PROLINE METHYL ESTER 98.00%
5MG
$ 496.33

Total 5 raw suppliers

Chemical Property of N-BOC-TRANS-4-IODO-L-PROLINE METHYL ESTER

Chemical Property:

Melting Point:63-65 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))
Boiling Point:359.7±42.0 °C(Predicted)
PKA:-5.07±0.60(Predicted)
PSA：55.84000
Density:1.56±0.1 g/cm3(Predicted)
LogP:1.91030

Purity/Quality:

95% ^*data from raw suppliers

N-BOC-TRANS-4-IODO-L-PROLINE METHYL ESTER 98.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-BOC-TRANS-4-IODO-L-PROLINE METHYL ESTER

There total 1 articles about N-BOC-TRANS-4-IODO-L-PROLINE METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 83548-49-6,83548-47-4
(2S,4S)-2-methyl 1-tert-butyl 4-iodopyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / Et₃N / CH₂Cl₂ / 8 h / Ambient temperature

2: 93.8 percent / Ph₃P, DEAD, CH₃I / tetrahydrofuran / 10 h / Ambient temperature

With triethylamine; triphenylphosphine; diethylazodicarboxylate; methyl iodide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(97)00617-4

Reference yield: 90.0%

: 83548-49-6,83548-47-4
(2S,4S)-2-methyl 1-tert-butyl 4-iodopyrrolidine-1,2-dicarboxylate

: 121147-97-5
1-tert-butyl 2-methyl (2S,4R)-4-azido-1,2-pyrrolidinedicarboxylate

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 65 ℃;

Reference yield: 70.0%

: 83548-49-6,83548-47-4
(2S,4S)-2-methyl 1-tert-butyl 4-iodopyrrolidine-1,2-dicarboxylate

: 73183-34-3
bis(pinacol)diborane

: 462637-32-7
1-(4-methoxycarbonylphenyl)-1-hexyne

: (2S)-1-tert-butyl 2-methyl 4-(1-(4-(methoxycarbonyl)phenyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)hex-1-en-1-yl)pyrrolidine-1,2-dicarboxylate

Guidance literature:: With 1,10-Phenanthroline; tributylphosphine; tetrabutylammomium bromide; triphenylphosphine; copper(l) chloride; sodium t-butanolate; In tetrahydrofuran; at 20 ℃; for 18h; Schlenk technique; Inert atmosphere;
DOI:10.1016/j.chempr.2021.06.002