1-(3-(2,5-difluorobenzyloxy)-3-(thiophen-2-yl)propyl)-1H-1,2,4-triazole

Base Information

Chemical Name:1-(3-(2,5-difluorobenzyloxy)-3-(thiophen-2-yl)propyl)-1H-1,2,4-triazole
CAS No.:1296877-09-2
Molecular Formula:C₁₆H₁₅F₂N₃OS
Molecular Weight:335.377
Hs Code.:

Synonyms:1-(3-(2,5-difluorobenzyloxy)-3-(thiophen-2-yl)propyl)-1H-1,2,4-triazole

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Chemical Property of 1-(3-(2,5-difluorobenzyloxy)-3-(thiophen-2-yl)propyl)-1H-1,2,4-triazole

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Technology Process of 1-(3-(2,5-difluorobenzyloxy)-3-(thiophen-2-yl)propyl)-1H-1,2,4-triazole

There total 3 articles about 1-(3-(2,5-difluorobenzyloxy)-3-(thiophen-2-yl)propyl)-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1296877-25-2
1-(thiophen-2-yl)-3-(1H-1,2,4-triazol-1-yl)propan-1-ol

: 85117-99-3
2-(bromomethyl)-1,4-difluorobenzene

: 1296877-09-2
1-(3-(2,5-difluorobenzyloxy)-3-(thiophen-2-yl)propyl)-1H-1,2,4-triazole

Guidance literature:: 1-(thiophen-2-yl)-3-(1H-1,2,4-triazol-1-yl)propan-1-ol; With potassium tert-butylate; In dimethyl sulfoxide; at 5 - 10 ℃;

2-(bromomethyl)-1,4-difluorobenzene; In dimethyl sulfoxide; at 20 ℃;
DOI:10.1016/j.ejmech.2011.02.021

Reference yield:

: 88-15-3,97511-16-5
2-Acetylthiophene

: 1296877-09-2
1-(3-(2,5-difluorobenzyloxy)-3-(thiophen-2-yl)propyl)-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water; isopropyl alcohol / 0.5 h / 90 - 95 °C / pH 4

2.1: ethanol; water / 90 °C

3.1: sodium tetrahydroborate / methanol / 2.5 h / 0 - 20 °C

4.1: potassium tert-butylate / dimethyl sulfoxide / 5 - 10 °C

4.2: 20 °C

With hydrogenchloride; sodium tetrahydroborate; potassium tert-butylate; In methanol; ethanol; water; dimethyl sulfoxide; isopropyl alcohol; 1.1: Mannich reaction;
DOI:10.1016/j.ejmech.2011.02.021

Reference yield:

: 103861-83-2
3-(pyrrolidin-1-yl)-1-(thiophen-2-yl)propan-1-one hydrochloride

: 1296877-09-2
1-(3-(2,5-difluorobenzyloxy)-3-(thiophen-2-yl)propyl)-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol; water / 90 °C

2.1: sodium tetrahydroborate / methanol / 2.5 h / 0 - 20 °C

3.1: potassium tert-butylate / dimethyl sulfoxide / 5 - 10 °C

3.2: 20 °C

With sodium tetrahydroborate; potassium tert-butylate; In methanol; ethanol; water; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.02.021