dimethyl 3-(4-(trifluoromethyl)phenyl)-1H-pyrrole-2,4-dicarboxylate

Base Information

• Chemical Name: dimethyl 3-(4-(trifluoromethyl)phenyl)-1H-pyrrole-2,4-dicarboxylate
• CAS No.: 1123725-60-9
• Molecular Formula: C₁₅H₁₂F₃NO₄
• Molecular Weight: 327.26
• Mol file: 1123725-60-9.mol

Synonyms:dimethyl 3-(4-(trifluoromethyl)phenyl)-1H-pyrrole-2,4-dicarboxylate

Chemical Property of dimethyl 3-(4-(trifluoromethyl)phenyl)-1H-pyrrole-2,4-dicarboxylate

Chemical Property:

Purity/Quality:

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Technology Process of dimethyl 3-(4-(trifluoromethyl)phenyl)-1H-pyrrole-2,4-dicarboxylate

There total 3 articles about dimethyl 3-(4-(trifluoromethyl)phenyl)-1H-pyrrole-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methyl 3-[4-(trifluoromethyl)phenyl]prop-2-ynoate (220652-97-1) + isocyanoacetic acid methyl ester (39687-95-1) → dimethyl 3-(4-(trifluoromethyl)phenyl)-1H-pyrrole-2,4-dicarboxylate (1123725-60-9)

Guidance literature:

With copper; In N,N-dimethyl-formamide; at 120 ℃; for 16h;

DOI:10.1002/chem.200801395

Reference yield: 69.0%

N-phenyl-1-(4-(trifluoromethyl)phenyl)methanimine oxide (162275-11-8,637038-27-8) + isocyanoacetic acid methyl ester (39687-95-1) → dimethyl 3-(4-(trifluoromethyl)phenyl)-1H-pyrrole-2,4-dicarboxylate (1123725-60-9)

Guidance literature:

With cesium acetate; copper(II) acetate monohydrate; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 20h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b00798

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) → dimethyl 3-(4-(trifluoromethyl)phenyl)-1H-pyrrole-2,4-dicarboxylate (1123725-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol; water / 0.08 h

2: copper(II) acetate monohydrate; cesium acetate / 1-methyl-pyrrolidin-2-one / 20 h / 80 °C / Inert atmosphere

With hydrogenchloride; cesium acetate; copper(II) acetate monohydrate; In 1-methyl-pyrrolidin-2-one; ethanol; water;

DOI:10.1021/acs.orglett.8b00798

upstream raw materials:

methyl 3-[4-(trifluoromethyl)phenyl]prop-2-ynoate

isocyanoacetic acid methyl ester

4-Trifluoromethylbenzaldehyde

N-phenyl-1-(4-(trifluoromethyl)phenyl)methanimine oxide