ortho-bis-[(3R,6S)-3,6-dihydro-5-ethoxy-6-isopropyl-3-methyl-pyrazin-2-one-3-methylene]benzene

Base Information

Chemical Name:ortho-bis-[(3R,6S)-3,6-dihydro-5-ethoxy-6-isopropyl-3-methyl-pyrazin-2-one-3-methylene]benzene
CAS No.:834883-04-4
Molecular Formula:C₂₈H₄₂N₄O₄
Molecular Weight:498.666
Hs Code.:

Synonyms:ortho-bis-[(3R,6S)-3,6-dihydro-5-ethoxy-6-isopropyl-3-methyl-pyrazin-2-one-3-methylene]benzene

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Chemical Property of ortho-bis-[(3R,6S)-3,6-dihydro-5-ethoxy-6-isopropyl-3-methyl-pyrazin-2-one-3-methylene]benzene

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Technology Process of ortho-bis-[(3R,6S)-3,6-dihydro-5-ethoxy-6-isopropyl-3-methyl-pyrazin-2-one-3-methylene]benzene

There total 4 articles about ortho-bis-[(3R,6S)-3,6-dihydro-5-ethoxy-6-isopropyl-3-methyl-pyrazin-2-one-3-methylene]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 834883-03-3
ortho-bis-[(3R,6S)-1-benzyl-3,6-dihydro-5-ethoxy-6-isopropyl-3-methyl-pyrazin-2-one-3-methylene]benzene

: 834883-04-4
ortho-bis-[(3R,6S)-3,6-dihydro-5-ethoxy-6-isopropyl-3-methyl-pyrazin-2-one-3-methylene]benzene

Guidance literature:: With ammonia; lithium; In tetrahydrofuran; tert-butyl alcohol; at -50 ℃;
DOI:10.1016/j.tetasy.2004.11.018

Reference yield:

: 91-13-4
α,α'-dibromo-o-xylene

: 834883-04-4
ortho-bis-[(3R,6S)-3,6-dihydro-5-ethoxy-6-isopropyl-3-methyl-pyrazin-2-one-3-methylene]benzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: LHMDS; Li / tetrahydrofuran / -78 °C

1.2: 85 percent / tetrahydrofuran

2.1: 80 percent / liquid ammonia; Li / tetrahydrofuran; 2-methyl-propan-2-ol / -50 °C

With ammonia; lithium; lithium hexamethyldisilazane; In tetrahydrofuran; tert-butyl alcohol; 2.1: Birch reaction;
DOI:10.1016/j.tetasy.2004.11.018

Reference yield:

: 433735-03-6
(6S)-1-benzyl-5-ethoxy-3,6-dihydro-6-isopropylpyrazine-2-one

: 834883-04-4
ortho-bis-[(3R,6S)-3,6-dihydro-5-ethoxy-6-isopropyl-3-methyl-pyrazin-2-one-3-methylene]benzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: LHMDS / tetrahydrofuran / 1 h / -78 °C

1.2: 65 percent / tetrahydrofuran

2.1: LHMDS; Li / tetrahydrofuran / -78 °C

2.2: 85 percent / tetrahydrofuran

3.1: 80 percent / liquid ammonia; Li / tetrahydrofuran; 2-methyl-propan-2-ol / -50 °C

With ammonia; lithium; lithium hexamethyldisilazane; In tetrahydrofuran; tert-butyl alcohol; 3.1: Birch reaction;
DOI:10.1016/j.tetasy.2004.11.018