433735-03-6

Basic information

• Product Name: 2(1H)-Pyrazinone, 5-ethoxy-3,6-dihydro-6-(1-methylethyl)-1-(phenylmethyl)-, (6S)-
• CAS NO: 433735-03-6
• Molecular Formula: C16H22N2O2
• Molecular Weight: 274.363
• Mol File: 433735-03-6.mol

Chemical Properties

• CAS DataBase Reference: 2(1H)-Pyrazinone, 5-ethoxy-3,6-dihydro-6-(1-methylethyl)-1-(phenylmethyl)-, (6S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrazinone, 5-ethoxy-3,6-dihydro-6-(1-methylethyl)-1-(phenylmethyl)-, (6S)-(433735-03-6)
• EPA Substance Registry System: 2(1H)-Pyrazinone, 5-ethoxy-3,6-dihydro-6-(1-methylethyl)-1-(phenylmethyl)-, (6S)-(433735-03-6)

Safety Data

• Hazardous Substances Data: 433735-03-6(Hazardous Substances Data)

Upstream product

• 433735-02-5 (S)-N-benzyl-N-chloroacetylvaline methyl ester 
• 40216-62-4 N-benzyl-L-valine methyl ester 
• 100-39-0 benzyl bromide 
• 4070-48-8 L-Valine methyl ester 
• 368-39-8 triethyloxonium fluoroborate 
• 427888-21-9 (2S)-1-N-benzyl-2-isopropyl-piperazine-3,6-dione 

Downstream Products

• 433735-04-7 1-[(3'R,6'S)-1'-benzyl-5'-ethoxy-3',6'-dihydro-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-5''-ethoxy-3'',6''-dihydro-6''-isopropylpyrazin-3''-yl-2''-one]propane 
• 618462-42-3 (3R,6S)-1-Benzyl-3-(3-chloro-propyl)-5-ethoxy-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one 
• 699009-62-6 1-[(3'R,6'S)-1'-benzyl-3',6'-dihydro-5'-ethoxy-6'-isopropylpyrazin-3'-yl-2'-one]-3-[(3''R,6''S)-1''-benzyl-3'',6''-dihydro-5''-ethoxy-6''-isopropylpyrazin-3''-yl-2''-one]-2-methylenepropane 
• 852853-42-0 (3R,6S)-1-benzyl-5-ethoxy-3-(4-chlorobutyl)-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one 
• 852853-41-9 (3R,6S)-1-benzyl-5-ethoxy-3-(2-chloromethylallyl)-6-isopropyl-3,6-dihydro-1H-pyrazin-2-one 
• 17609-47-1 L-Valine ethyl ester hydrochloride 
• 17431-03-7 L-valine ethyl ester 

Relevant articles and documents

Orthogonally Protected Sch?llkopf's Bis-lactim Ethers for the Asymmetric Synthesis of α-Amino Acid Derivatives and Dipeptide Esters

Alkylation of the aza-enolates of orthogonally protected chiral bis-lactim ethers with electrophiles proceeds with good levels of diastereocontrol to afford trans-alkylated adducts that can be efficiently deprotected via hydrolysis/hydrogenation procedures to afford non-proteinogenic α-amino acid or dipeptide ester derivatives.

A new stereocontrolled synthesis of uncommon tripeptides derived from 2,6-diaminopimelic acid (2,6-DAP)

The stereocontrolled synthesis of uncommon tripeptides 8 and 11a-c, structural variants of 2,6-diaminopimelic acid, was carried out starting from the mono-lactim ether 1 easily obtained from L-valine. The configurations of the introduced stereogenic centers were assigned on the basis of 1H NMR spectroscopic data.